度洛西汀与帕罗西汀治疗抑郁症的临床疗效的Meta分析

目的:系统评价度洛西汀与帕罗西汀治疗抑郁症的临床疗效。方法:全面检索万方医学网数据库的相关文献,筛选度洛西汀与帕罗西汀治疗抑郁症的对照研究,按照纳入与排除标准选择试验、评价质量并提取有效数据,采用RevMan4.2软件进行Meta分析,评价治疗6周后的痊愈率、有效率以及治疗2周末时的汉密尔顿抑郁量表(HAMD)评分。结果:共纳入5项研究,合计443例病例。Meta分析结果显示,6周末时度洛西汀和帕罗西汀的痊愈率分别为46.60%和38.62%,差异无统计学意义OR=1.41,95%CI(0.93,2.41),P=0.11];临床有效率为76.44%和71.43%,差异也无统计学意义OR=1.30,95%CI(0.82,2.06),P=0.26];2周末HAMD评分比较,差异有统计学意义WMD=-1.17,95%C(I-1.99,-1.34),P=0.006]。结论:2种药物的远期疗效相当,但度洛西汀比帕罗西汀起效更加迅速。

Meta-analysis of Cfinical Efficacy of Dutoxetine and Paroxetine in the Treatment of Depression

OBJECTIVE： To evaluate clinical efficacy of dutoxetine and paroxetine in the treatment of depression. METHODS ： Retrieved from Wanfang database, Rev Man 4.2 software was adopted for meta-analysis of included study. Cure rate and effective rate were evaluated 6 weeks later. HAMD score was evaluated at the end of second week. RESULTS： A total of 5 studies were in- cluded, involving 443 patients. Results of Meta-analysis showed that cure rates of dutoxetine and paroxetine were 46.60% and 38.62% at the end of sixth week, there was no statistical significance between 2 groups OR=1.41, 95%CI （0.93, 2.41）, P= 0.11]. Clinical effective rate of 2 groups were 76.44% and 71.43%, there was no statistical significance between 2 groups OR= 1.30,95%CI（0.82, 2.06） ,P=0.26]. HAMD scores were analyzed at the end of second week, there was statistical significance in difference between 2 groups WMD = -- 1.17,95 % CI （ -- 1.99, -- 0.34）, P= 0.006]. CONCLUSION ： 2 drugs are same in long-term efficacy, but onset time of dutoxetine is earlier than that of paroxetine.