维生素K_1注射液、硫酸镁注射液与阿托品注射液的配伍稳定性考察

目的:考察维生素K1注射液、硫酸镁注射液与阿托品注射液的配伍稳定性。方法:观察及测定3种注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后于室温下避光放置24h内的外观、pH值及不溶性微粒数,并采用高效液相色谱法测定配伍液中维生素K1、阿托品的含量,用火焰原子吸收分光光度法测定配伍液中硫酸镁的含量。结果:在避光24h内,维生素K1、硫酸镁及阿托品在0.9%氯化钠和5%葡萄糖注射液中的外观、pH值、不溶性微粒数及含量均无明显变化。结论:在避光条件下,维生素K1注射液、硫酸镁注射液及阿托品注射液在24h内可以配伍使用。

Compatible Stability of Vitamin K1 Injection, Magnesium Sulfate Injection and Atropine Injection

OBJECTIVE： To investigate the compatible stability of Vitamin K1 injection, Magnesium sulfate injection and Atro- pine injection. METHODS： The changes in appearance, insoluble particles and pH value of the compatible solutions of these three injections in 0.9% Sodium chloride injection and 5% Glucose injection were observed within 24 h at the ambient temperature and protected from light. The contents of vitamin K~ and atropine were determined by HPLC. The content of magnesium sulfate was de- termined by AAS. RESULTS： No obvious changes in the appearance, pH value, insoluble particle number and contents of vitamin K1 magnesium, sulfate and atropine in 0.9% Sodium chloride injection and 5% Glucose injection were demonstrated at the condition of being protected from light within 24 h. CONCLUSION： Vitamin K1 injection, Magnesium sulfate injection and Atropine sulfate injection are shown to be compatible at the condition of being, protected from light within 24 h