MMP-9 R279Q基因多态性与冠心病易感性的Meta分析

 目的 探讨MMP-9 R279Q基因多态性与冠心病易感性的关系。方法 检索PubMed，获取2012年1月1日以前发表的MMP-9 R279Q基因多态性与冠心病易感性的病例-对照研究。以冠心病组与对照组人群基因型分布的OR值及95%CI为效应指标，在纯合子比较模型、显性模型和隐性模型中采用固定效应方法进行合并分析, 并进行偏倚评估，应用STATA11.0软件进行统计学处理。结果 共纳入文献5篇，在MMP-9 R279Q多态性位点，基因型比较模型中合并OR值为0.925 (95% CI = 0.847-1.009)，纯合子比较模型合并OR值为0.866 (95% CI = 0.713-1.052)，显性模型合并OR值为0.909 (95% CI = 0.809-1.020)，隐性模型合并OR值为0.902 (95% CI = 0.750-1.086)。结论 MMP-9 R279Q基因多态性可能与冠心病易感性无关。

MMP-9 R279Q polymorphism and susceptibility to coronary heart disease: a meta-analysis

Objective To investigate the relationship between matrix metalloproteinase-9 (MMP-9) gene polymorphism and genetic susceptibility to coronary heart disease. Methods A Meta-analysis on MMP-9 R279Q polymorphism and susceptibility to coronary heart disease was performed by searching for studies included in PubMed before January 1, 2012. For each study, odds ratios (ORs) and 95% confidence intervals (CIs) was calculated to assume homozygote comparison, dominant and recessive genetic models. Pooled ORs and 95% CIs was calculated and publication bias was assessed. All statistical analyses were conducted by STATA 11.0 software. Results A total of 5 case-control studies were analyzed in the study. The MMP-9 R279Q QQ genotype was not associated with the risk of coronary heart disease compared with R279Q RR genotype (QQ vs. RR: OR=0.866; 95%CI=0.713-1.052). Effect estimates from a dominant model (QQ + RQ) vs. RR: OR= 0.909; 95%CI=0.809-1.020] or a recessive model QQ vs. (RQ + RR):OR=0.902; 95%CI=0.750-1.086] suggest that the MMP-9 R279Q variants are not associated with coronary heart disease risk. Conclusion MMP-9 R279Q gene polymorphism may not be associated with genetic susceptibility to coronary heart disease.