枸杞糖肽治疗非酒精性脂肪肝的临床研究

目的：探讨枸杞糖肽胶囊治疗非酒精性脂肪肝的疗效和药物不良反应。方法：采用随机对照研究，非酒精性脂肪肝患者82例，分为两组，每组41例，治疗组应用枸杞糖肽胶囊30mg po bid，对照组给予肝泰乐片200mg po tid，疗程均为6个月。治疗前和治疗3个月、6个月后记录两组患者的临床症状、肝功能（ALT、AST、TBil、GGT）、血脂（TG、TC、LDL-C、HDL-C）、B超结果，同时观察药物不良反应。结果：治疗组有效率70．7％，优于对照组（P〈0，05）。与3个月疗程比较差异有显著性意义（P〈0．05）。两组患者治疗后的ALT、AST、GGT明显下降，血脂各项指标明显改善，尤其在治疗组治疗前后比较差异有显著性意义（P〈0．01或P〈0．05）。用药过程中治疗组出现1例不良反应。结论：枸杞糖肽胶囊治疗非酒精性脂肪肝疗效显著，并且具有良好的安全性，延长疗程可增加疗效。

Clinical research of fructus lycii glucopeptide on patients with nonalcoholic fatty liver disease

Objective： To investigate the therapeutic effect and adverse reaction of fructus lycii glucopeptide on patients with nonalcoholic fatty liver disease. Methods： By random control study, 82 cases of NAFLD were divided into 2 groups （41 cases, respectively） . The patients in treatment group were administrated with caps of fructus lycii glucopeptide （30mg po bid）, while the patients in control group were treated with tabs of glucurolactone （200mg po tid）, both lasting 6 months. The clinical manifestations, liver function （ALT, AST, TBil, GGT）, blood fat （TG, TCh, LDL-C, HDL-C）, type-B ultrasonic findings and drug adverse reactions were observed and recorded before treatment and after 3-month or 6-month treatment. Results： The effective rate of 6-month treatment group （70. 7% ） was higher than that of control group （P 〈0. 05） , and also higher than 3-month treatment group （ P 〈 O. 05 ） . The level of ALT, AST, GGT were significantly decreased after treatment in both groups, with a favorable turn about all the items associated with blood fat. The above changes were especially apparent in treatment group compared with its per-treatment counterpart （P 〈 O. O1 or P 〈 O. 05 ）, showing a better therapeutic effect than in con- trol group （ P 〈 O. O1 or P 〈 O. 05 ） . There was one case in the treatment group manifesting adverse reaction during the therapy. Conclusion： Fructus lycii glucopeptide has a marked therapeutic effect on the patients with NAFLD, and a good safety in clinic application. A longer course of treatment produces a better therapeutic effect.