| 地塞米松对庆大霉素和丁胺卡那霉素所致豚鼠耳毒性的保护作用 |
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| 引用本文： | 朱新波,金晓冬,董缪武,林丹. 地塞米松对庆大霉素和丁胺卡那霉素所致豚鼠耳毒性的保护作用[J]. 中国临床药理学与治疗学, 2003, 8(6): 659-661 |
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| 作者姓名： | 朱新波 金晓冬 董缪武 林丹 |
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| 作者单位： | 温州医学院药理教研室,温州,325027,浙江 |
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| 基金项目： | 浙江省温州市科技局基金资助项目(№01025) |
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| 摘 要： | 目的：观察地塞米松能否拮抗庆大霉素和丁胺卡那霉素所致的耳毒性。方法：取听力正常的豚鼠50只，雌雄各半，随机分为5组：庆大霉素组；丁胺卡那霉素组；庆大霉素 地塞米松组；丁胺卡那霉素 地塞米松组和生理盐水对照组。用药2wk后饲养1wk，检查中耳粘膜反应、眼震抑制率及耳蜗的形态学变化。结果：庆大霉素 地塞米松组与庆大霉素组比较；丁胺卡那霉素 地塞米松组与丁胺卡那霉素组相比有显著性差异。结论：地塞米松对庆大霉素与丁胺卡那霉素所造成的耳毒性有明显的保护作用。
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| 关 键 词： | 地塞米松 庆大霉素 丁胺卡那霉素 耳毒性 豚鼠 |
| 文章编号： | 1009-2501(2003)06-0659-03 |
| 修稿时间： | 2003-07-07 |
Protective effects of dexamethasone against ototoxicity in guinea pigs |
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| ZHU Xin-Bo,JIN Xiao-Dong,DONG Miao-Wu,LIN Dan. Protective effects of dexamethasone against ototoxicity in guinea pigs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(6): 659-661 |
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| Authors: | ZHU Xin-Bo JIN Xiao-Dong DONG Miao-Wu LIN Dan |
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| Affiliation: | ZHU Xin-Bo,JIN Xiao-Dong,DONG Miao-Wu,LIN Dan Department of Pharmacology,Wenzhou Medical College,Wenzhou 325027,Zhejiang,Ch ina |
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| Abstract: | AIM: To study the protective effects of dexamethasone agains t ototoxicity of aminoglycoside antibiotics in guinea pigs. METHODS: Guinea pigs were divided into five groups. Group One: gentamycin, im; Group Two: amikacin, im; Group Three: gentamycin+ dexamethasone, im; Group Four: amika cin+ dexamethasone,im; Group Five: NS, im, all for two weeks. After three weeks, all animals were examined including tympanic mucous membrane reaction, nystagmu s depression rates and cochleae morphology. RESULTS: In Group Th ree and Four, the changes of morphology were slighter than those in Group One an d Two. CONCLUSION: Dexamethasone can weaken ototoxicity of amino glycoside antibiotics. |
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| Keywords: | dexamethasone gentamycin am ikacin ototoxicity guinea pigs |
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