| HPLC法测定辛伐他汀片的含量 |
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| 引用本文： | 岳一涛.HPLC法测定辛伐他汀片的含量[J].安徽医药,2011,15(9):1082-1083. |
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| 作者姓名： | 岳一涛 |
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| 作者单位： | 安徽省淮南市第一人民医院,安徽,淮南,232007 |
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| 摘 要： | 目的建立一种辛伐他汀片中辛伐他汀含量的HPLC的测定方法。方法选用Techsphere ODS色谱柱(250 mm×4.6mm,5μm),乙腈-0.025%mol.L-1磷酸二氢钠溶液(pH=4.5)(65:35)为流动相,洗脱流速为1.0 ml·min-1,检测波长为238 nm。结果辛伐他汀在42.4~424.0 mg·L-1浓度范围内线性关系良好(r=0.999 6);平均回收率为99.6%,RSD=1.24%(n=6)。结论该方法简便,灵敏,易行,准确,适用于辛伐他汀的测定。
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| 关 键 词： | 高效液相色谱法 辛伐他汀片 |
Determination of simvastatin in simvastatin tablets by HPLC |
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| YUE Yi-tao.Determination of simvastatin in simvastatin tablets by HPLC[J].Anhui Medical and Pharmaceutical Journal,2011,15(9):1082-1083. |
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| Authors: | YUE Yi-tao |
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| Institution: | YUE Yi-tao(Huainan First People＇s Hospital,Huainan,Anhui 232007) |
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| Abstract: | Aim To establish an HPLC method for determination of simvastatin in simvastatin tablets.Methods TECHSPHERE ODS column（250 mm×4.6 mm,5 μm）was adopted,with acetonitrile-0.025mol·L-1sodium phosphate monobasic（pH=4.5）（65：35） as mobile phase.The detector wavelength was set at 238 nm,and the flow rate was 1.0 ml·min-1.Results Calibration curve was linear over the range of 42.4~424.0 mg·L-1（r=0.999 6）.For potency assay the mean recovery was 99.6% with RSD as 1.24%（n=6）.Conclusion The method is simple,sensitive and accurate.which was suitable for quantitative detection of simvastatin. |
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| Keywords: | HPLC simwastatin tablets |
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