转换生长因子β1联合胎球蛋白 A 预测放射性肺炎初探简

目的 研究转换生长因子β1（TGF-β1）及胎球蛋白A（Fetuin A）与放射性肺炎（ RP）的关系,探讨两者联合预测PR的价值.方法 2010年5月~2012年02月,126例符合研究条件接受三维适型放疗的肺癌患者.放疗前、后行血清TGF-β1及Fetuin-A检测.随访半年,根据增强CT结果结合临床症状诊断RP.结果 126例患者发生RP为A组（33例）,未发生RP为B组（93例）.两组放射治疗前血清TGF-β1及Fetuin-A水平无统计学差异（P均〉0.05）;与B组比较,放射治疗后A组血清TGF-β1水平升高,而Fetuin-A水平降低（P均＜0.05）;放疗后、前TGF-β1≥1患者中46.15%发生了PR;放疗后、前Fetuin-A＜1患者中52.54%发生了PR;放疗后、前TGF-β1≥1且Fetuin A＜1患者中66.67%发生了PR.结论联合转换生长因子β1及胎球蛋白A的动态变化对PR的发生有一定预测作用.

Clinical study of prediction of radiation pneumonia with serum transforming growth factor beta-1 and fetuin A

Objective To study the relationship of transforming growth factor beta-1 （TGF-β1） and fetuin A with radiation pneumonia （RP）. Methods 126 patients with lung cancer were treated with three-dimensional con- formal radiation therapy （RT）. Their levels of serum TGF-β1 and fetuin A were measured before and after the radia- tion therapy. All the patients were followed-up for six months. RP was diagnosed based on contrasted thorax CT combined with clinical symptoms. Results 126 patients were divided into the group A （n = 33 ） and the group B （n = 93 ） based on RP. There was no significant difference in TGF-β1 and fetuin A levels between the groups before the treatment （P 〉 0. 05 ）. After the treatment, the level of TGF-β1 was higher in the group A than in the group B, while the level of fetuin A was lower in the group A than in the group B. 46. 15% patients with TGF-β1 ratio higher than 1 and 52. 54% patients with Fetuin-A ratio less than 1 were complicated with RP. Conclusion The combined detec- tion of TGF-β1 and fetuin A could predict the occurrence of RP.