血浆同型半胱氨酸、NO 致 COPD 的发展机制研究简

目的 分析慢性阻塞性肺病急性加重期（AECOPD）患者血浆同型半胱氨酸（Hcy）、一氧化氮（NO）、一氧化氮合酶（NOS）及超敏C反应蛋白（hs-CRP）的关系及意义,并探讨其对COPD的作用机制.方法 测定54例AECOPD患者血浆tHcy、NO、NOS、hs-CRP水平,并与60例正常对照组比较.结果 AECOPD患者血浆tHcy和hs-CRP与正常对照组比较均显著性增高（P〈0.01）,NO和NOS与正常对照组比较均显著性降低（P〈0.01）.tHcy与NO、NOS呈负相关（r分别是-0.57、-0.49）,与hs-CRP呈正相关（r是0.48）,（P〈0.01）.结论 COPD患者血浆存在低NO和高Hcy,二者参与COPD的氧化应激和炎症反应,加重了COPD 病情的发展.

Research on mechanism of COPD caused by plasma homocysteine and NO

Objective To study the significance of homocysteine （Hcy）, nitric oxide （NO）, nitric oxide synthase （NOS） and high sensitive C reactive protein（hs-CRP） in the mechanism of AECOPD patients. Methods The levels of plasma Hey, NO, NOS, hs - CRP were determined in 54 patients with AECOPD and 60 healthy con- tnds. Results The levels of tHey and hs - CRP were significantly higher, and the levels of NO and NOS were signif- icantly lower in the nbservation group than in the control groap （P 〈0.01 ）. Hey was negatively correlated with NO and NOS （ r = - 0. 57, - 0. 49） , and positively correlated with hs-CRP （ r = 0. 48 ） （ P 〈 0. 01 ）. Conclusion There exists a low level of NO and a high level of Hcy in plasnta of COPD patients, which lake part in oxidative strress and inllanmmtory reaction in COPD and increase the development of C（）t）I） disease.