| The cloning of Na+/Ca2+exchaanger Gene and its expression in brain ischemia |
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| 引用本文： | Tang Jian汤健,Wang Yu王瑜,Zkang Chenhui张晨晖,E. Costa Institute of Cardiovascular Research,Beijing Medical University. The cloning of Na+/Ca2+exchaanger Gene and its expression in brain ischemia[J]. 北京大学学报(医学版), 1994, 0(Z1) |
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| 作者姓名： | Tang Jian汤健 Wang Yu王瑜 Zkang Chenhui张晨晖 E. Costa Institute of Cardiovascular Research Beijing Medical University |
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| 作者单位： | Tang Jian汤健，Wang Yu王瑜，Zkang Chenhui张晨晖，E. Costa Institute of Cardiovascular Research，Beijing Medical University |
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| 摘 要： | ＴＨＥＣＬＯＮＩＮＧＯＦＮａ￣＋／Ｃａ￣（２＋）ＥＸＣＨＡＮＧＥＲＧＥＮＥＡＮＤＩＴＳＥＸＰＲＥＳＳＩＯＮＩＮＢＲＡＩＮＩＳＣＨＥＭＩＡＴａｎｇＪｉａｎ汤健，ＷａｎｇＹｕ王瑜，ＺｋａｎｇＣｈｅｎｈｕｉ张晨晖，Ｅ．ＣｏｓｔａＩｎｓｔｉｔｕｔｅｏｆＣａｒ...
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THE CLONING OF Na+/Ca2+ EXCHANGER GENE AND ITS EXPRESSION IN BRAIN ISCHEMIA |
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| Abstract: | It is known that intracellular Ca2+ is overloaded during ischemia,and at the same tirne,the activity of one of the major pathways of ca2+ efluxs-Na+/Ca2+ exchanger is altered.However,the molecular mechanism of this alteration is still unknown. We cloned a 456bp cDNA fragment of rat cerebellar Na+/Ca2+ exchanger gene.Using this fragment as the probe,We found that the Na+ /Ca2+ exchanger mRNA is widely distributed in rat central and peripheral nervous system,such as in cerebra, heart,lung, and kidney. Using focal cerebral ischemic model,We de-tected the gene expression of Na+/Ca2+ exchanger in ischemic brain by Northern blotting and in situ hybridization,and found that in ischemic tissues,the mRNA level of Na+/Ca2+ exchanger is lowered. |
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| Keywords: | Na2+/Ca2+exchanger lschemia Gene expression Ca2+efflux mRNA |
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