16698例宫颈液基细胞学判读结果研究

目的评价液基细胞薄层制片技术(LCT)在宫颈病变筛查中的临床应用价值,从而进一步研究宫颈癌发病情况及液基细胞学检查在妇科疾病诊断中的意义。方法利用液基薄层细胞制片技术(LCT)对16 698例宫颈标本进行细胞学检查,按Bethesda诊断系统(TBS)作出诊断,并对结果进行回顾性分析。结果 16 698例宫颈标本中,不满意标本57例,占0.34%;上皮细胞异常(阳性病例)1276例,占7.64%;鳞状细胞癌(SCC)21例,占0.12%;腺癌(AC)5例,占0.02%;高级别鳞状上皮内病变(HSIL)142例,占0.85%;低级别鳞状上皮内病变(LSIL)452例,占2.71%;非典型鳞状上皮细胞,不排除高级别鳞状上皮内病变(ASC-H)37例,占0.22%;非典型鳞状上皮细胞,意义不明确(ASC-US)581例,占3.47%;非典型腺细胞(AGC)38例,占0.22%;未见上皮内病变或恶性病变(NILM)15 364例,占92.07%。结论 LCT和TBS系统能全面准确地反映宫颈病变情况。早期发现癌前病变,及时治疗,阻止宫颈上皮内病变升级是防治宫颈癌的关键。

Results Analysis of 16 698 Cases in Liquid-Based Cervical Cytology

Objective Assess the value of liquid-based cytology technology(LCT)in the diagnosis of cervix disease,for further study cervix carcinoma incidence rate and liquid-based cytology technology in the diagnosis in gynecology disease.Methods Thin prep liquid-based cytological examination was used in 16 698 patients.TBS report grading system was used in cytological diagnosis and retrospective analyses the result.Results 16 698 copies of the results of cervical cytology results showed:0.34%(57/16 698)cases is unsatisfactory,abnormal epithelial patterns was 7.64%(1276/16 698),squamous cell carcinoma(SCC)was 0.12%(21/16 698),adenocarcinoma(AC) was 0.02%(5/16 698),high-grade squamous intraepithelial lesions(HSIL)was 0.85%(142/16 698),low-level squamous intraepithelial lesion(LSIL)was 2.71%(452/16 698),atypical aquamous cells cannot exclude high-grade aquamous intraepithelial leision(ASC-H) was 0.22%(37/16 698),atypical squamous cells of undetermined significance(ASCUS) was 3.47%(581/16 698),atypical glandular cells was 0.22%(38/16 698),negative for intraepithelial ledion or malignancy(NILM) was 92.07%(15 364/16 698).Conclusion LCT production methods and TBS get a better grasp of the diagnostic criteria which ensure the accuracy of cervical cytology and early detection precancerous lesions,immediate treatment is the key to prevent development of cervix lesions.