Bone metastases in primary operable breast cancer. The role of a yearly scintigraphy |
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| Affiliation: | 1. Department of Diagnostic Radiology, Herlev Hospital, University of Copenhagen, Herlev, Denmark;2. Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark;3. Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, Denmark;4. Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital, Copenhagen, Denmark;5. Central Laboratory, Holbæk Hospital, Holbæk, Finseninstitutet/University Hospital, Copenhagen, Denmark;6. DBCG Secretariat, Finseninstitutet/University Hospital, Copenhagen, Denmark;1. Department of Surgery, Faculty of Medicine, Thammasat University Hospital, Thammasat University, Pathum Thani, Thailand;2. Center of Excellence in Applied Epidemiology, Faculty of Medicine, Thammasat University Hospital, Thammasat University, Pathum Thani, Thailand;3. Department of Surgery, Chonburi Hospital, Chonburi, Thailand;4. Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;5. Health Intervention and Technology Assessment Program (HITAP), Department of Health, Ministry of Public Health, Nonthaburi, Thailand;6. Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;1. Division of Neurosurgery, Azienda Ospedaliero–Universitaria Maggiore della Carità, Novara, Italy;2. Department of Clinical Surgical Diagnostic and Pediatric Sciences, Università degli Studi di Pavia, Pavia, Italy;3. Division of Neurosurgery, Azienda Socio Sanitaria Territoriale Monza–Ospedale San Gerardo, Monza, Italy;1. Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, Indiana;2. Medical University of South Carolina, Charleston, SC;1. Department of Neurosurgery, Albany Medical Center, 47 New Scotland Avenue, MC 10, Albany, NY 12208, USA;2. Department of Anesthesiology, Albany Medical Center, 47 New Scotland Avenue, MC 10, Albany, NY 12208, USA |
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| Abstract: | In 231 patients with primary operable breast cancer bone scintigraphies were performed yearly from the second of the 6th year until recurrence irrespective of localization was diagnosed, another cancer was detected, or the patient refused further follow-up or died. During the observation period (from 2 up to 7 years after surgery) 13 patients (5.6%) had bone metastases verified by X-ray or histology within 12 months after the last bone scintigraphy. The scintigraphy was positive in only 7 of these patients. The yearly incidence of bone metastases varied between 0.6 and 2.6%. Due to this low incidence and a low cost/benefit, we conclude that a fixed schedule of repeated scintigraphies in primary operable breast cancer patients otherwise free of apparent disease is not justified. |
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