Evaluation of a totally implanted venous access port and portable pump in a continuous chemotherapy infusion schedule on an outpatient basis |
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| Affiliation: | 1. Department of Internal Medicine, Division of Medical Oncology, University Hospital Groningen, The Netherlands;2. Department of Surgery, Division of Surgical Oncology, University Hospital Groningen, The Netherlands;1. Harvard Medical School, Massachusetts General Hospital, United States;2. Anesthesia, Massachusetts General Hospital, Boston, MA 02114, United States;3. Burn Center, Municipal Hospital #8, Lviv, Ukraine;4. Shriners Hospital for Children, Boston, MA 02114, United States;5. Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 012114, United States;1. Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, the Netherlands;2. Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands;1. Service d’anesthésie et de réanimation, Hôpital Nord, Assistance Publique–Hôpitaux de Marseille, Aix Marseille Université, Marseille, France;2. Service de réanimation DRIS, Hôpital Nord, Assistance Publique–Hôpitaux de Marseille, Aix Marseille Université, Marseille, France;3. Service de gynécologie et d’obstétrique, Hôpital Nord, Assistance Publique–Hôpitaux de Marseille, Aix Marseille Université, Marseille, France;4. Unité d’Aide Méthodologique à la Recherche Clinique et Épidémiologique, Aix Marseille Université, Marseille, France;5. Centre d’Investigation Clinique 1409, Aix Marseille Université, Assistance Publique–Hôpitaux de Marseille, Marseille, France;1. College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 712-749, Republic of Korea;2. College of Pharmacy, Chung-Ang University, 221 Heuksuk-dong Dongjak-gu, Seoul 156-756, Republic of Korea;3. College of Pharmacy, Hanyang University, 55, Hanyangdaehak-ro, Sangnok-gu, Ansan 426-791, Republic of Korea |
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| Abstract: | In this study we evaluated the feasibility of a totally implanted vascular access port (VAP) and portable infusion pump for cytostatic drug administration on an outpatient basis, in a 21-day continuous infusion schedule with 4-epidoxorubicin (phase I and phase II study) and mitoxantrone (phase I study). Patients were instructed to dissolve their own drugs at home. Fifty patients were treated with 114 cycles (2394 infusion days). The complication rate was low. In one patient thrombosis of the subclavian and superior caval vein resulted in the termination of treatment. One patient developed pulmonary embolism during treatment. Needle dislocation was observed in two patients. No septicaemia and no irreversible catheter occlusion were seen. Pump functioning was efficient and pump arrest (9 ×) never lasted longer than 24 h. We conclude that a VAP and portable pump are a safe and reliable route of administration for cytostatic drugs on an outpatient basis and that patients are capable of preparing their own drugs at home without increase of complications. |
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