Relation between leukaemic cell count and degree of maturation in acute myeloid leukaemia |
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| Affiliation: | 1. Department of Haematology, Free University, Amsterdam, The Netherlands;2. Department of Pediatrics Free University, Amsterdam, The Netherlands;3. Department of Medical Statistics, Free University, Amsterdam, The Netherlands;1. Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran;3. Department of Medical Laboratory, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;4. Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;1. Department of Oncology and Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy;2. University of Milan, Milan, Italy;3. University of Milan-Bicocca, Monza, Italy;1. Department of Hematology, Institut Paoli-Calmettes, Marseille, France;2. Department of Hematology, University Hospital Centre L′Archet, Nice, France;3. Department of Hematology and Cellular Therapy, La Conception Hospital, Marseille, France;4. Aix-Marseille University, INSERM U1068, CNRS, Institut Paoli-Calmettes, CRCM, Marseille, France;5. Department of Molecular Biology, Institut Paoli-Calmettes, Marseille, France;6. Department of Molecular Biology, Hôpital Nord, Marseille, France;7. SMARTc: Simulation and Modeling: Adaptative Response for Therapeutics in Cancer, Marseille, France;8. Faculté de Pharmacie de Marseille, CRCM Inserm UMR, Marseille 1068, France;9. Pharmacy, Hôpital de la Conception, Marseille, France;10. Department of Pathology and Molecular Oncology, University Hospital Centre L’Archet, Nice, France;11. INSERMU1065, C3M / Cote d′Azur University; Nice, France |
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| Abstract: | In acute myeloid leukaemia the peripheral leukocyte count is known to be a prognostic factor. The preserved capacity of leukaemic cells to mature has also been suggested to be one. In a series of 179 cases of adult acute myeloid leukaemia peripheral leukaemic cell count and degree of maturation were found to be inversely correlated. As the degree of maturation of leukaemic cells in peripheral blood was lower than that in bone marrow in the majority of cases, blast cells appear to be released more easily from the marrow than cells that have matured to some extent in the direction of the larger promyelocytic or promonocytic cell type. In a series of 35 cases we found peripheral blast cells to be smaller than those in bone marrow. Moreover, central blast cell diameter and peripheral leukaemic cell count were inversely correlated. Therefore, leukaemic cell size or some factor related to it may contribute to the preferential egress of small immature cells from the marrow. Differences in proliferative activity could not account for the inverse correlation between degree of maturation and leukaemic cell count. |
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