Interferon gamma regulates HLA-D expression on solid tumors in vivo |
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| Affiliation: | 1. Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China;2. Tianjin General Surgery Institute, Tianjin Medical University General Hospital, Tianjin 300052, China;3. Department of Vascular Surgery, Tianjin Fourth Central Hospital, Tianjin 300140, China;1. Department of Laparoscopy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;2. The First Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China;1. Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore;2. Humanised Mouse Unit, Institute of Molecular and Cell Biology, A*STAR, 61 Biopolis Drive, Singapore 138673, Singapore;3. Department of Anatomical Pathology, Singapore General Hospital, Singapore;4. Singapore Immunology Network, A*STAR, 8A Biomedical Grove, Immunos Building, Level 4, Singapore 138648, Singapore;5. Department of Medical Oncology, National Cancer Centre, Singapore;6. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, National University Hospital, National University Health System, Singapore;7. CRC “A.M. e A. Migliavacca” Center for the Study of Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca'' Granda - Ospedale Maggiore Policlinico, Milan, Italy;8. Fred Hutch Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA, USA;9. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore;1. Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, USA;2. Department of Surgery, University of California Davis, Sacramento, CA, USA |
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| Abstract: | In vivo administration of recombinant human interferon-γ, rIFN-γ, to nude mice bearing human tumor xenografts resulted in a strong induction of HLA-DR expression on the tumor cells in 2 of 3 lines tested. The induction was dose-dependent and declined rapidly after cessation of therapy. IFN-γ also switched on DQ and DP products when the xenograft cells were treated in vitro. The in vivo alteration of tumor surface properties by rIFN-γ may have therapeutic implications. |
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