Chemotherapy of germ-cell ovarian tumours: First-line treatment with etoposide,bleomycin and cisplatin or carboplatin |
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| Institution: | 1. Department of Radiotherapy, The Royal Marsden Hospital, London, U.K.;2. The Institute of Cancer Research and The Royal Marsden Hospital, Surrey, U.K.;1. Civil and Environmental Engineering Department, Universiti Teknologi PETRONAS, 32610, Perak, Malaysia;2. Civil Engineering Department, Bayero University, Kano, Nigeria;1. Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China;2. School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;3. State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240 China;4. State Key Laboratory of Traction Power, Southwest Jiaotong University, Chengdu 610031, China;1. Department of Urology, Medical Faculty, University of Duesseldorf, Germany;2. Department of Urology, University Hospital Bonn, Germany;3. Department of Urology, Kliniken Essen-Mitte, Essen, Germany;4. Department of Urology, Federal Armed Services Hospital, Koblenz, Germany;5. Department of Urology, Asklepios Klinik, Altona, Hamburg, Germany;6. Department of Urology, University Hospital, Cologne, Germany;7. Department of Urology, Städtisches Klinikum, Dortmund, Germany;8. Department of Urology, Ernst-Moritz Arndt University, Greifswald, Germany;9. Department of Urology, Städtisches Krankenhaus, Kiel, Germany;10. Department of Clinical and Surgical Andrology, University Hospital Münster, Germany;11. Department of Urology, Theresien Krankenhaus Mannheim, Germany;12. Department of Medical Biometry, Informatics, and Epidemiology, Bonn, Germany;13. Institute of Pathology, Vivantes Klinikum am Urban, Berlin, Germany;14. Institute of Pathology, University of Leipzig, Germany;15. Department of Urology, Military Hospital, Hamburg, Germany;1. Department of Physiology, Faculty of Basic Medical Sciences, PAMO University of Medical Sciences, Port Harcourt, Rivers State, Nigeria;2. Department of Physiology, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria |
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| Abstract: | Of 9 patients with malignant ovarian germ-cell tumours (OGCT) treated with combination chemotherapy between 1980 and 1985, 8 are alive and disease-free at 6–62 months. All patients received etoposide and bleomycin and 8 out of 9 also received a platinum analogue; in one case carboplatin, in a second carboplatin plus cisplatin, and in the remainder, cisplatin. In one patient treated prior to the introduction of carboplatin, poor renal function precluded the use of cisplatin. Two patients with Stage III dysgerminomas are disease-free at 44 and 62 months after receiving chemotherapy followed by radiotherapy to the whole abdomen or pelvis. Of 7 patients with non-dysgerminomatous OGCT, including 2 dysgerminomas with raised serum alphafetoprotein, 6 are disease-free at 6–56 months.On the basis of these observations and experience reported elsewhere, surveillance after removal of the primary tumour is proposed for early-stage dysgerminoma, and chemotherapy is suggested for advanced presentations as an alternative to surgery and post-operative radiotherapy. Combination chemotherapy is indicated for all stages of non-dysgerminomatous OGCT. |
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