Renal function in Inuit survivors of epidemic hemolytic-uremic syndrome |
| |
| Authors: | Malcolm R. Ogborn Lorraine Hamiwka Elaine Orrbine David S. Newburg Atul Sharma Peter N. McLaine Pamela Orr Peter Rowe |
| |
| Affiliation: | (1) Department of Pediatrics and Child Health, University of Manitoba, AE208-840 Sherbrook Street, Winnipeg, Manitoba R3 A 1S1, Canada, CA;(2) CPKDRC, Children’s Hospital of Eastern Ontario, Canada, CA;(3) Department of Pediatrics, University of Ottawa, Children’s Hospital of Eastern Ontario, Canada, CA;(4) Department of Biomedical Sciences, Schriver Center, and Harvard Medical School, Boston, Massachusetts, USA, US;(5) Department of Pediatrics, McGill University, Montreal, Quebec, Canada, CA;(6) Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada, CA;(7) Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA, TP |
| |
| Abstract: | We undertook a case-control study to evaluate the renal health of survivors of hemolytic-uremic syndrome (HUS) from the 1991 Arctic epidemic of Escherichia coli 0157:H7 gastroenteritis 4 years after the epidemic. Eighteen children who developed HUS during the 1991 epidemic and 18 age- and sex-matched controls from the same community who had uncomplicated gastroenteritis were compared in 1995 for height, weight, blood pressure, urinalysis, and glomerular filtration rate (GFR), measured using continuous subcutaneous infusion of non-radioactive iothalamate. HUS survivors did not differ from controls in height, weight, systolic (HUS 118 mmHg, control 117 mmHg) or diastolic (HUS 64 mmHg, control 62 mmHg) blood pressures. Hematuria was detected more frequently in HUS survivors (11/18 vs. 4/18, P<0.05), but no child had proteinuria. Mean GFR did not differ between the two groups (HUS 159 ml/min per 1.73 m2, control 147 ml/min per 1.73m2). Survivors of post-enteritic HUS from the 1991 Arctic E. coli 0157:H7 outbreak have excellent renal function 4 years after the epidemic. Received September 18, 1997; received in revised form February 3, 1998; accepted February 4, 1998 |
| |
| Keywords: | : Hemolytic-uremic syndrome Inuit Renal function Iothalamate Glomerular filtration rate |
| 本文献已被 SpringerLink 等数据库收录！ |
|
