The relationship between impairment of voluntary movements and cognitive impairment in Huntington’s disease |
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Authors: | Jiří Klempíř Olga Klempířová Jan Štochl Nataša Špačková Jan Roth |
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Institution: | 1.1st Medical Faculty, Department of Neurology,Charles University,Prague 2,Czech Republic;2.Faculty of Physical Education and Sport, Department of Kinanthropology,Charles University,Prague,Czech Republic |
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Abstract: | The relationship between motor symptoms and cognitive impairment in Huntington’s disease (HD) is still discussed. We analysed
45 HD patients in various stages using Unified Huntington’s Disease Rating Scale motor subscale (voluntary and involuntary
components were evaluated separately), verbal memory and executive functions tests. Partial correlations controlling for HD
duration and age were used to estimate the relationships among factor scores for motor and cognitive impairment. Voluntary
components of motor performance were found to be significantly correlated with verbal short-term memory disturbances (r = −0.361, P = 0.03), with tests of executive functions more dependent on motor performance (r = 0.640, P < 0.01) and also with tests of executive functions less dependent on motor performance (r = 0.461, P < 0.01). Involuntary components did not correlate significantly with any part of cognitive performance. |
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