Affiliation: | 1. Centre de recherche de l’hôpital du Sacré-C?ur de Montréal, 5400, boulevard Gouin Ouest, Montréal, Québec H4J1C5, Canada;2. Département de Psychologie, Université du Québec à Montréal, 100, rue Sherbrooke Ouest, Montréal, Québec H2X3P2, Canada;3. Département de Chirurgie, Université de Montréal, 2900, boulevard Édouard-Montpetit, Montréal, Québec H3T1J4, Canada;4. Unité de neuroimagerie fonctionnelle, Centre de recherche de l’institut de gériatrie de Montréal, 4545, chemin Queen-Mary, Montréal, Québec H3W1W4, Canada |
Abstract: | ObjectivesThe present aging study investigated the impact of a multisession anodal-tDCS protocol applied over the primary motor cortex (M1) during motor sequence learning on generalization of motor learning and plasticity-dependent measures of cortical excitability.MethodsA total of 32 cognitively-intact aging participants performed five consecutive daily 20-min sessions of the serial-reaction time task (SRTT) concomitant with either anodal (n?=?16) or sham (n?=?16) tDCS over M1. Before and after the intervention, all participants performed the Purdue Pegboard Test (PPT) and Transcranial Magnetic Stimulation (TMS) measures of cortical excitability were collected.ResultsRelative to sham, participants assigned to the anodal-tDCS intervention revealed significantly greater performance gains on both the trained SRTT and the untrained PPT as well as a greater disinhibition of long-interval cortical inhibition (LICI). Generalization effects of anodal-tDCS significantly correlated with LICI disinhibition.ConclusionAnodal-tDCS facilitates motor learning generalisation in an aging population through intracortical disinhibition effects.SignificanceThe current findings demonstrate the potential clinical utility of a multisession anodal-tDCS over M1 protocol as an adjuvant to motor training in alleviating age-associated motor function decline. This study also reveals the pertinence of implementing brain stimulation techniques to modulate age-associated intracortical inhibition changes in order to facilitate motor function gains. |