| 多重耐药鲍曼不动杆菌存在新的氨基糖苷类药物耐药机制 |
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| 引用本文： | 朱健铭,姜如金,糜祖煌. 多重耐药鲍曼不动杆菌存在新的氨基糖苷类药物耐药机制[J]. 世界感染杂志, 2008, 8(1): 20-23 |
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| 作者姓名： | 朱健铭 姜如金 糜祖煌 |
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| 作者单位： | 浙江省杭州市余杭区中医院,浙江,杭州,311106;江苏省无锡市克隆遗传技术研究所,江苏,无锡,214026 |
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| 摘 要： | 目的了解多重耐药鲍曼不动杆菌（MDR—ABA）是否存在新的氨基糖苷类药物耐药机制。方法采用PCR检测30株MDR—ABA菌12种16SrRNA甲基化酶和氨基糖苷类修饰酶基因。结果9株检出16SrRNA甲基化酶基因（30．0％），29株检出氨基糖苷类修饰酶基因（96．7％）。结论MDR—ABA菌存在新的氨基糖苷类药物耐药机制。
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| 关 键 词： | 鲍曼不动杆菌 16SrRNA甲基化酶 |
New mechanisms of aminoglycoside drug resistance exist in multi-drug-resistant strains of Acinetobacter baumannii |
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| Affiliation: | ZHU Jian-ming, JIANG Ru-jin Mi Zu-huang (1Hangzhou Yuhang hospital of traditional Chinese medicine, Hangzhou, 311106,China; 2Wuxi Clone Gen-Tech Istitute, Wuxi, 214026, China) |
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| Abstract: | Objective To investigate the new mechanisms of aminoglycoside drug resistance existing in multi-drug-resistant strains of Acinetobacter baumannii （MDR-ABA）. Methods The genes of 12 kinds 16SrRNA methylase and aminoglycoside-modifying enzymes were detected by polymerase chain reaction （PCR）. Results In 30 MDR-ABA strains, 9 strains carried 16SrRNA methylase gene（armA）, 29 strains were positive for the genes of aminoglycoside-modifying enzymes. Conclusions The new mechanisms of aminoglycoside drug resistance exist in MDR-ABA. |
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| Keywords: | Acinetobacter baumannii 16SrRNA methylase |
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