强骨饮对去势大鼠股骨颈骨形态计量学影响的实验研究

目的观察自拟强骨饮对去势SD大鼠股骨颈骨形态计量学指标的影响。方法随机将SD大鼠造模成功后分成强骨饮组和福善美组,每组各20只。应用自拟强骨饮与福善美治疗,分别在治疗过程中1.5,3,4.5,6个月处死大鼠,取股骨颈标本,进行骨形态计量学检测,分别对治疗前后骨形态计量学指标变化及有效率进行观察和统计学分析。结果1.5个月和3个月福善美组指标改善情况好于强骨饮组,4.5个月两组数据已比较接近,6个月数据比较,强骨饮组数据均好于福善美组。结论强骨饮能有效的提高骨形态计量学指标,且中远期疗效尤为突出,可能是因为其能有效地刺激成骨作用,有效地抑制破骨细胞活性作用来实现的。

Effect of Qiangguyin on Collum Femoris of the Ovariectomized Rats in the Area of Histomorphome

OBJECTIVE To observe the effect of Qiangguyin on cllum femoris of the ovariectomized rats in the area of histomorphone.METHODS Randomly to divide the ovariectomized SD rats into the Qiangguyin group and the Fushanmei group,each group 20 rats and use the Qiangguyin and Fushanmei separetly.In the course of treatment,at 1.5,3,4.5,6 months,the rats were killed,and have the collum femoris was taken for the detection and analysis of the histomorphome index. RESULTS The Fushanmei index of the 1.5 and 3 months is good than that of the Qiangguyin.The 4.5 months index is close between Qiangguyin and Fushanmei.The Qiangguyin index of the 6 months is better than that of the Fushanmei.CONCLUSION Qiangguyin has a significant effect on osteoporosis in the mid and later treatment course.The mechanism probably reluted with the stimulating effect of osteogenesis and inhibition of osteoclast activity.