Hydronidone for the Treatment of Liver Fibrosis Related to Chronic Hepatitis B: A Phase 2 Randomized Controlled Trial |
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| Affiliation: | 1. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China;2. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China;3. Core Facility Center for Medical Sciences, The First Affiliated Hospital of USTC, Hefei, China;4. Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China;5. Department of Infectious Diseases, China-Japan Friendship Hospital, Beijing, China;6. Department of Infectious Diseases, the Third People’s Hospital of Zhenjiang, Jiangsu Province, China;7. Department of Infectious Diseases, Henan Provincial People’s Hospital, Henan Province, China;8. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China;9. Center for Liver Diseases, 905th Hospital of PLA Navy, Shanghai, China;10. Department of Infectious Diseases, Peking University First Hospital, Beijing, China;11. Continent Pharmaceuticals, Beijing, China |
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| Abstract: | |
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| Keywords: | Chronic Hepatitis B Hydronidone Liver Fibrosis Regression ALT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" alanine transaminase AST" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" aspartate transaminase CHB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" chronic hepatitis B CI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" confidence interval HBV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" hepatitis B virus HBeAg" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" hepatitis B virus e antigen HBsAg" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" hepatitis B surface antigen ICC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" intraclass correlation coefficient ITT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" intention-to-treat LSM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" liver stiffness measurement NA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" nucleos(t)ide analogue PC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" progression to cirrhosis PF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" progression of fibrosis RC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" regression of cirrhosis RF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0175" }," $$" :[{" #name" :" text" ," _" :" regression of fibrosis SAEs" },{" #name" :" keyword" ," $" :{" id" :" kwrd0185" }," $$" :[{" #name" :" text" ," _" :" serious adverse events TBil" },{" #name" :" keyword" ," $" :{" id" :" kwrd0195" }," $$" :[{" #name" :" text" ," _" :" total bilirubin TGF-β" },{" #name" :" keyword" ," $" :{" id" :" kwrd0205" }," $$" :[{" #name" :" text" ," _" :" transforming growth factor-beta ULN" },{" #name" :" keyword" ," $" :{" id" :" kwrd0215" }," $$" :[{" #name" :" text" ," _" :" upper limit of normal |
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