Th1/Th2 Cytokine Profile and Its Diagnostic Value in Mycoplasma pneumoniae Pneumonia |
| |
| Authors: | Wei Li Yu-jie Liu Xiao-le Zhao Shi-qiang Shang Lang Wu Qing Ye Hui Xu |
| |
| Institution: | 1.Department of Clinical Laboratory, Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China;2.Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA |
| |
| Abstract: | Background:The levels of Th1/Th2 cytokine can alter in pathogenic infection in children with pneumonia.Objectives:To evaluate Th1/Th2 cytokine profile and its diagnostic value in M. pneumoniae pneumonia in children.Patients and Methods:Children with M. pneumoniae mono-infection and 30 healthy children were tested with cytokines assay. We used real time PCR to detect M. pneumoniae in children with pneumonia.Results:M. pneumoniae test was positive in 2188 (16.62%) out of 13161 pneumonia children. Children aged 5 - 9 years had the highest rate and summer was a season with high rate of M. pneumoniae incidence in Zhejiang province. During the course of study, in 526 pneumonia children with M. pneumoniae mono-infection and 30 healthy children cytokines assay was performed. IL-2 level of M. pneumoniae pneumonia children was lower than that of healthy children (median levels, pg/mL: IL-2: 3.2 vs. 5.7, P = 0.00), while IL-4, IL-10 and IFN-γ were higher than in healthy children (median levels, pg/mL: IL-4: 3.2 vs. 1.5, P = 0.00; IL-10: 5.6 vs. 2.5, P = 0.001; IFN-γ: 20.4 vs. 4.8, P = 0.001).Conclusions:IL-2 decreases and IL-4, IL-10 and IFN-γ increase in children with M. pneumoniae pneumonia, which has a promising prospect in diagnosis of this disease in clinical practice. |
| |
| Keywords: | Cytokines Pneumonia Children M pneumoniae |
|
|
