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Effectiveness of Meningococcal B Vaccine against Endemic Hypervirulent Neisseria meningitidis W Strain,England |
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| Authors: | Shamez N. Ladhani Marzia Monica Giuliani Alessia Biolchi Mariagrazia Pizza Kazim Beebeejaun Jay Lucidarme Jamie Findlow Mary E. Ramsay Ray Borrow |
| Affiliation: | St. George’s University of London Paediatric Infectious Diseases Research Group, London, UK (S.N. Ladhani); ;Public Health England, London (S.N. Ladhani, K. Beebeejaun, M.E. Ramsay); ;GSK Vaccines, Siena, Italy (M.M. Giuliani, A. Biolchi, M. Pizza); ;Public Health England, Manchester, UK (J. Lucidarme, J. Findlow, R. Borrow) |
| Abstract: | Serum samples from children immunized with a meningococcal serogroup B vaccine demonstrated potent serum bactericidal antibody activity against the hypervirulent Neisseriameningitidis serogroup W strain circulating in England. The recent introduction of this vaccine into the United Kingdom national immunization program should also help protect infants against this endemic strain. |
| Keywords: | Neisseria meningitidis meningococcal W disease ST11 clonal complex prevention meningococci serum bactericidal antibody activity immunization endemic meningitis Bexsero Menveo England vaccine bacteria |