Chemotherapy for patients with advanced lung cancer receiving long-term oxygen therapy |
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Authors: | Manabu Hayama Hidekazu Suzuki Takayuki Shiroyama Motohiro Tamiya Norio Okamoto Ayako Tanaka Naoko Morishita Takuji Nishida Takashi Nishihara Tomonori Hirashima |
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Affiliation: | Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino City, Japan |
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Abstract: | BackgroundLong-term oxygen therapy (LTOT) is sometimes prescribed for patients with advanced lung cancer who are potential candidates for chemotherapy. The aim of this study was to assess the usefulness of chemotherapy for patients with this disease who require LTOT.MethodsThe medical records of 40 patients with advanced lung cancer who received LTOT while undergoing systemic chemotherapy at our institution between January 2009 and December 2014 were retrospectively reviewed. Chemotherapy consisted of cytotoxic or molecular-targeted agents.ResultsTwenty-four patients had adenocarcinoma, 6 had squamous cell carcinoma, and 10 had small cell lung cancer (SCLC). The median survival time from the date of the first chemotherapy cycle performed in conjunction with LTOT was 194 days. In a multivariate analysis, the only factor significantly associated with better prognosis was the line (first or second) of the first chemotherapy with LTOT (hazard ratio =0.42; 95% confidence interval, 0.18 to 0.94). Among the 40 patients, 10 (25%) received chemotherapy during the last 30 days of their lives, 2 of whom died of chemotherapy-related adverse events.ConclusionsChemotherapy for patients with advanced lung cancer who receive LTOT may be acceptable if it is the first- or second-line treatment. However, we should be mindful of the potential overuse of chemotherapy and its negative impact on quality of life. |
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Keywords: | Lung cancer chemotherapy comorbidity long-term oxygen therapy (LTOT) performance status |
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