骨质疏松与勃起功能障碍风险相关性的Meta分析

目的采用Meta分析的方法,评估骨质疏松与勃起功能障碍(ED)之间风险相关性。方法检索PubMed、Cochrane Library、Embase、Web of Science、Springer Link、中国知网、万方等数据库,检索时间截止至2018年12月,数据提取由2名研究员独立进行,以避免错误或遗漏。任何分歧可通过小组商讨共识或咨询第3位研究员来解决。对纳入的研究采用Stata 12.0软件进行Meta数据分析。结果最终有4篇病例-对照研究文献符合此Meta分析的纳入标准。其中共纳入了4702例ED患者。Meta分析结果显示:各研究间不存在显著异质性(I2=46.4%,P=0.133)。因I2<50%,从而对该Meta分析采取固定效应模型。ED组骨质疏松的患者显著高于非ED组患者(P<0.05)。采用漏斗图法和Begg、Egger检验对对纳入研究的发表偏倚进行评估,最终未发现发表偏倚。敏感性分析采用逐次剔除法,合并效应值RR取值于1.48~1.61,剔除后的研究对结果影响不大,总合并效应值与其基本一致。结论通过研究发现ED患者合并骨质疏松的风险明显高于非ED患者,ED患者可能存在雄性激素与雌性激素水平的失平衡,而这种平衡被打破后,可能会让骨质疏松的发生率升高。这也侧面反映了性激素对于骨质疏松的重要性。

Correlation between osteoporosis and risk of erectile dysfunction: a Meta-analysis

Objective To evaluate the risk correlation between osteoporosis and erectile dysfunction(ED).Methods Databases such as PubMed,Cochrane Library,Embase,web of science,Springer Link,CNKI and Wanfang Date were searched from the present study to December 2018.Data extraction was conducted independently by two authors to avoid errors or omissions.Any disagreement can be resolved by a group consensus or by consulting a third author.Data analysis of the included studies was conducted by Stata 12.0 software.Results Four case-control studies were included in this analysis,including a total of 4702 patients with ED.The Meta-analysis showed that:There was no significant heterogeneity among the studies(I2=46.4%,P=0.133).Since I2<50%,a fixed effect model was adopted for this Meta-analysis.Patients in the ED group had significantly more osteoporosis than those in the non-ED group(P<0.05).The publication bias of the included studies was accessed by funnel chart method and Begg Egger test,and no publication bias was found.Sensitivity analysis was carried out one by one,and the results showed that the RR of the combined effect size after excluding the single literature fluctuated between 1.48 and 1.61,which was basically consistent with the total combined effect size.Conclusions The risk of osteoporosis in ED patients is significantly higher than that in non-ED patients.ED patients may have imbalance of androgen and estrogen levels,and when this imbalance occurs,it may increase the incidence of osteoporosis,which also reflects the importance of sex hormones for osteoporosis.