烧伤创面应用硝酸铈的实验研究

为探讨硝酸铈的应用价值,比较了烧伤创面行硝酸铈湿敷和早期切痂对严重烧伤后大鼠存活率和 T 细胞亚群变化的影响。结果表明:大鼠30%TBSA Ⅲ度烧伤后第14天,存活率低,外周血 Th/Ts 比值显著降低,而烧伤后早期手术切痂或创面硝酸铈湿敷则能明显提高大鼠存活率和外周血 Th/Ts比值。认为,早期切痂或创面硝酸铈湿敷均有防止烧伤后 T 细胞 Th/Ts 比值下降和提高存活率的作用。烧伤休克期,如不具备早期手术切痂的条件,用硝酸铈湿敷是一种简便有效的治疗方法。

Effects of wound wet dressing with cerium nitrate on cell-mediated immunity after severe burn.

Suppression of cell-mediated immunity(CM)and lowering of survival rate follow major thermal injury are associated with absorptiion of burn toxin.Wistar rats received 30% full-thickness burn,and were then treated with early burn excision or wet dressing of cerium nitrate for the wound.At day 14 postburn,both survival rates and peripheral blood Th/Ts rate were monitored.It was found that both excision and cerium nitrate could prevent marked lowering of surrival rate and Th/Ts ratio were monitored.It was found that both excision and cerium nitrate could prevent markly lowering of survival rates and Th/Ts ratio induced by severe burn.This indicated that CE,in the early postburn days,may replace early burn excision to prevent the suppression of CMI following severe burn.