糖化血红蛋白和尿微量白蛋白联合检测对2型糖尿病肾病早期诊断的临床意义

目的探讨糖化血红蛋白（HbA1c）和尿微量白蛋白（U-mAlb）联合检测对2型糖尿病肾病早期诊断的临床意义。方法选取100例2型糖尿病患者,依据患者肾功能指标（尿素氮、肌酐、尿酸）正常与否,将其分为非临床DN组（A组）61例、临床DN组（B组）39例,选取健康体检者40例作为对照组,对选取样本进行HbA1c、U-mAlb检测。结果 A、B组U-mAlb、HbA1c指标与对照组相比,差异具有统计学意义（P〈0.05）,B组U-mAlb、HbA1c指标与A相比,差异具有统计学意义（P〈0.05）。结论 HbA1c和U-mAlb两者联合检测对DN的早期诊断、治疗和病情监测具有重要的临床价值。

Clinical significance of glycosylated hemoglobin and micro-albuminuria combined detection in early diagnosis of type 2 diabetic nephropathy

Objective To discuss clinical significance of glycosylated hemoglobin（HbA1c） and microalbuminuria（U-mAlb） combined detection in early diagnosis of type 2 diabetic nephropathy. MethodsAccording to whether patients＇ renal function indexes（urea nitrogen, creatinine, uric acid） were normal or not, 100 patients with type 2 diabetes were divided into early no-clinical DN group（group A） 61 cases, clinical DN group（group B） 39 cases. The test of HbA1 c and U-mAlb were measured in 100 type 2 diabetes patients and 40 healthy individuals, then compared among three groups. Results The results of HbA1 c and U-mAlb in diabetic group were significantly higher than those of control group（P〈0.05）. The HbA1 c and U-mAlb in group B were significantly higher than those of group A（P〈0.05）. Conclusion The detection of HbA1 c and U-mAlb inpatients with type 2 diabetes has important clinical value for the early diagnosis of diabetic nephropathy.