血管细胞黏附分子-1和P-选择素对急性冠脉综合征的预测价值

目的研究血清可溶性血管细胞黏附分子-1、P-选择素水平在急性冠状动脉综合征中的特点，探讨其对急性冠脉综合征的预测价值。方法用酶联免疫吸附法检测21例急性心肌梗死（AMI），23例不稳定型心绞痛，22例稳定型心绞痛（SAP）和20例健康对照者血清sVCAM-1、sP-选择素水平。结果ACS患者血清（UAP）sVCAM-1、sP-选择素水平均高于非ACS患者，AMI患者血清sVCAM-1浓度及sP-选择素水平较UAP患者升高（均P〈0．05）。以x±2s为临界值联合检测ACS的灵敏度为73．4％，特异度为84．2％。结论ACS患者血清VCAM-1、P-选择素水平升高，提示与ACS的发生有关，是动脉粥样硬化斑块不稳定的标志，可以作为ACS的预测指标。

Prediction value of serum VCAM-1 and serum P-selection.in acute coronary syndrome

Objective To investigate the difference and relationships of serum VCAM-1and P-selection levels in different subtype of coronary heart diseases and explore the potential predicting factors for the acute coronary syndrome(ACS).Method The levels of serum sVCAM-1 and sP-selection in 21 cases of acute myocardial infarction(AMI),23 cases of unstable angina pectoris(UA),22 cases of stable angina pectoris(SA) and 20 cases of normal healthy control subjects were measured by ELISA method,comparing the values of sVCAM-1 and sP-selection among different group.Result Serum sVCAM-1 and sP-selection levels were significantly higher in the ACS group compared with normal group.For ACS,the sensitivity was 73.4 %,specificity was84.2 %with serum sVCAM-1 and sP-selection levels.Conclusion The elevated VCAM-1 and P-selection levels suggested an obvious relationship with pathogenesis of ACS,which may be a potential markers of plaque instability and may be newly sensitive markers for identifying patients with ACS.