寻常型银屑病遗传模式分析

目的 探讨寻常型银屑病可能的遗传模式。方法 应用Penrose法、Falconer回归法及SAGE－REGTL软件对1043例银屑病患者及家系进行复合分离分析和遗传度计算，以探讨银屑病的可能遗传模式。结果 1043例寻常型银屑病患者中，有家族史者305例（29.24%)，无家族史者738例（70.76%)；Penrose法计算，s/q接近1／q；一级、二级亲属的遗传度分别是0.670和0.466；通过复合分离分析不符合单基因显性、隐性、共显性遗传模式及环境模式和非主基因模式。结论 遗传分析提示寻常型银屑病不符合单基因遗传，而属于多基因遗传模式或多因子遗传模式。

Analyses of genetic model of psoriasis vulgaris

Objective To explore the possible genetic model of psoriasis vulgaris. Methods The complex segregation analysis and heritability calculation were performed with the aid of Penrose method, Falconer regression method and SAGE-REGTL program. Results It was found that in 1043 patients with psoriasis vulgaris ,305 patients (29.24%) have the family history of psoriasis, and 738 patients have not the family history. A ratio of s/q approached 1/q with Penrose method, and the heritability values of psoriasis in the first-degree and second-degree relatives were 67.04%,46.6% respectively. By complex segregation analysis, Mendelian, non-major-gene model and environment model were rejected for psoriasis. Conclusion The results suggest that psoriasis follows a pattern of polygenetic or multifactorial inheritance rather than single-gene inheritance.