LATE-ONSET GM2 GANGLIOSIDOSIS PRESENTING AS BURNING DYSESTHESIAS |
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Authors: | Chow GCS Clarke JTR Banwell BL |
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Institution: | Canadian Journal of Neurological Sciences 28: 191–198, 2001. Reprinted with permission from the Canadian Journal of Neurological Sciences, Inc. |
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Abstract: | Peripheral polyneuropathy is the most frequent complication of diabetic mellitus. In spite of many clinical trials of different specific interventions for diabetic polyneuropathy, intensive glycemic control remains the only effective specific therapy currently available for this troublesome complication. This systematic overview reports the status of current clinical trials in diabetic polyneuropathy with an emphasis on those interventions directed towards specific pathophysiological derangements. A discussion of clinical trials of agents directed towards relieving painful symptoms of diabetic polyneuropathy concludes this overview. |
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