可溶性血管细胞黏附分子-1与2型糖尿病及其并发症的相关性研究

目的探讨血清可溶性血管细胞黏附分子-1(sVCAM-1)与2型糖尿病及其并发症的关系.方法采用酶联免疫吸附法测定61例合并高血压和微血管并发症的糖尿病患者及36例正常人血清中sVCAM-1水平.结果2型糖尿病患者的sVCAM-1水平[(973.25±73.38)μg/L]明显高于非糖尿病患者[(230.45±12.47)μg/L],P＜0.001.合并高血压患者sVCAM-1[(1263.99±87.00)μg/L]较微血管病变者[(726.57±95.40)μg/L]增高更明显(P＜0.001).结论sVCAM-1参与了糖尿病血管并发症的发生和发展.

Relationship between circulating vascular cell adhesion molecule-1 and vascular complications in type 2 diabetes mellitus

OBJECTIVE: To investigate the relationship between soluble vascular cell adhesion molecule-1 (sVCAM-1) and type 2 diabetes complicated with vascular diseases. METHODS: In 61 cases of type 2 diabetes with macrovascular or microvascular complications and 36 cases of healthy control, sVCAM-1 levels were measured in duplicate by enzyme-linked immunosorbent assay using the soluble VCAM-1 Kit (R& D Systems Ltd, Ablingdon, Oxfordshire, UK). RESULTS: sVCAM-1 levels in type 2 diabetes [(973.25 +/- 73.38) microg/L] were higher than these of healthy controls [(230.45 +/- 12.47) microg/L], P < 0.001. sVCAM-1 levels of type 2 diabetes with hypertension [(1263.99 +/- 87.00) microg/L] were higher than those of type 2 diabetes with microvascular complications [(726.57 +/- 95.40) microg/L], P < 0.001. CONCLUSION: There was a significant correlation between sVCAM-1 concentration and vascular complications of type 2 diabetes.