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| 尼古丁对帕金森病大鼠纹状体GDNF和多巴胺含量的影响 | |
| 引用本文： | 朱晓临,管绯,童萼塘,孙圣刚. 尼古丁对帕金森病大鼠纹状体GDNF和多巴胺含量的影响[J]. 临床神经病学杂志, 2002, 15(3): 139-141 |
| 作者姓名： | 朱晓临 管绯 童萼塘 孙圣刚 |
| 作者单位： | 1. 471003,洛阳市东方医院神经科 2. 471003,洛阳市东方医院心内科 3. 武汉华中科技大学协和医院神经科 |
| 摘 要： | 目的 研究尼古丁对帕金森病（PD）大鼠纹状体脑胶质细胞源性神经营养因子(GDNF)和多巴胺（DA）含量的影响。方法 将6－羟多巴胺（6－OHDA）立体定向注射到大鼠右侧中脑腹侧背盖部（VTA）和黑质致密部（SNpc)，建立PD大鼠模型。采用生化、免疫组织化学方法观察不同剂量尼古丁对PD大鼠的作用，检测纹状体GDNF表达及DA含量的变化。结果 造模前及造模后皮下注射尼古丁的PD大鼠，纹状体GDNF表达及DA含量较PD组有明显改善（P＜0．05）。结论 尼古丁可减轻6－OHDA对黑质DA能神经元的损伤，对PD大鼠具有保护作用。 |
| 关 键 词： | 尼古丁 帕金森病 脑胶质细胞源性神经营养因子 多巴胺 |
| 文章编号： | 1004-1648(2002)03-0139-03 |
| 修稿时间： | 2001-09-19 |
Effects of nicotine on GDNF and dopamine content in striatum of Parkinson''''s disease rats |
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| Zhu Xiaolin,Guan Fei,Tong Etang,et al.. Effects of nicotine on GDNF and dopamine content in striatum of Parkinson''''s disease rats[J]. Journal of Clinical Neurology, 2002, 15(3): 139-141 | |
| Authors: | Zhu Xiaolin Guan Fei Tong Etang et al. |
| Affiliation: | Zhu Xiaolin,Guan Fei,Tong Etang,et al.Department of Neurology,Dong Fang Hospital,Luoyang 471003 |
| Abstract: | Objective To study the effects of nicotine on GDNF and dopamine content in striatum of Parkinson's disease (PD) rats.Methods 6-OHDA was stereoscopically injected to right side of the mesencephic ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc). Nicotine of different dosages was intraperitoneally injected into PD rats.With biochemical,immunohistochemical techniques, we observed the changes of GDNF expression and dopamine content in striatum.Results Nicotine was intraperitoneally injected into PD rat models before or after the operation,striatum GDNF expression and DA content had significant improvement as compared with PD group (P< 0.05).Conclusion Nicotine may lighten the damage of 6-OHDA in neurons of substantia nigra,and has protective effect to PD rats. |
| Keywords: | Nicotine Parkinson's disease GDNF DA |
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