动态观察乳腺癌手术前后血小板参数及凝血功能变化对病情发展及疗效评价的意义

目的探讨乳腺癌手术前后血小板参数及凝血功能变化对病情发展的临床意义。方法用全自动血球计数仪SF-3000以及凝血仪检查乳腺癌80例和良性乳腺疾病80例术前及术后全血以及凝血功能。结果乳腺癌患者术前组PLT、MPV与对照组差异无统计学意义（P〉0．05），而与术后组差异有统计学意义（P〈0．05）；PDW差异无统计学意义（P〉0．05）；术后组与对照组PLT、MPV差异有统计学意义（P〈0．05），而PCT及PDW差异无统计学意义（P〉0．05）；乳癌手术前后凝血酶原时间（PT）差异无统计学意义（P〉0．05），而纤维蛋白原含量（FiB）术后明显高于术前（P〈0．05）；活化部分凝血酶原时间（APTT）术后明显低于术前（P〈0．05）。结论动态观察乳腺癌手术前后血小板参数可能作为一个新的预后因子，而凝血功能变化可作为判断患者病情发展及疗效评价的参考指标，对防治乳腺癌具有重要的临床意义。

Changes of Platelets and Blood Prothrombin Time, Fibrinogen Content in Patients with Breast Carcinoma at Preoperation and Postoperation

Objective To explore the significance of blood platelets and prothrombin time(PT),active partial thromboplastin time(APTT) and fibrinogen content (FiB) in postoperative patients with breast carcinoma.Methods PLT of 80 patients with breast carcinoma and 80 patients with benign breast diseases were examined with automated hematology analyzers SF-3000 and PT,APTT and FiB were examined with German PE automated coagulation analyzer at preoperation and postoperation.Results Breast carcinoma at the preoperation group compared with the control group,results of PLT,MPV were no significantly changes(P>0.05),but at the postoperation group,there were significant changes(P<0.05),result of PDW was no significant changes(P>0.05),the postoperation group compared with the control group,results of PLT,MPV were significant changes(P<0.05),but PCT,PDW were no significant changes(P>0.05);The PT was no significant changes at preoperation and postoperation(P>0.05).FiB content at postoperation was significantly higher than that at preoperation.(P<0.05);The APTT at postoperation was significantly lower than that at preoperation(P<0.05).Conclusions PLT maybe a new prognostic factor for breast carcinoma,blood prothrombin time,fibrinogen content maybe play an important role in patients with breast carcinoma at preoperation and postoperation.So we must attach importance to study its value.