1型糖尿病TAP基因多态性的Meta分析

目的 用Meta分析的方法综合评价国内外有关TAP基因各位点多态性与1型糖尿病关联性的研究.材料与方法 检索中国生物医学文献数据库、MEDLINE和EMBASE数据库,收集所有相关的病例对照试验,应用RevMan4.2软件对符合条件的所有研究结果进行Meta分析,包括异质性检验、合并效应量以及评估发表偏倚.结果 符合纳入标准的共12篇文献.TAP1-333V/V纯合子、TAP2-665A/T杂合子可能是1型糖尿病的保护性基因型,合并OR值及其95%置信区间分别为0.31（0.16,0.59）和0.46（0.30,0.72）,P＜0.05;TAP2D单倍体型可能是1型糖尿病的保护性单倍体型,其合并OR值和95%置信区间为0.67（0.47,0.93）,P＜0.05.TAP2F单倍体型可能是1型糖尿病的易感性单倍体型,其合并OR值和95%置信区间为2.51（1.62,3.90）,P＜0.05.结论 1型糖尿病与TAP基因的多态性可能具有关联性.

TAP Gene Polymorphism in Type 1 Diabetes Mellitus(A Meta-analysis of Case-control Trials)

Objective Evaluate all the studies about the association of TAP gene polymorphism and type 1 diabetes mellitus with meta-analysis.Material and Method Search was conducted on the following electronic databases:Chinese Bio-medicine Database,MEDLINE,EMBASE to identify all the relevant case-control trials.Statistical analysis was performed with RevMan4.2 to investigate heterogeneity,to combine the studies and to evaluate the publication bias.Results Totally 12 studies were recruited.TAP1-333-V/V,TAP2-665A/T might confer the protection for type 1 diabetes mellitus,their pooled OR and 95%CI were 0.31(0.16,0.59) and 0.46 (0.30,0.72) respectively (P < 0.05).TAP2D haplotype might confer the protection for DM-1,the pooled OR and 95%CI were 0.67 (0.47,0.93)(P < 0.05).TAP2F haplotype might confer the susceptibility to type 1 diabetes mellitus,the pooled OR and 95%CI were 2.51 (1.62,3.90)(P < 0.05).Conclusion TAP gene polymorphism might be associated with type 1 diabetes mellitus.