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| 子宫内膜异位症患者血清及腹腔液中血小板衍生生长因子、血管细胞粘附分子水平的变化及其意义 | |
| 引用本文： | 阎华,许俊华,郭淑青,耿永巧,李立粉. 子宫内膜异位症患者血清及腹腔液中血小板衍生生长因子、血管细胞粘附分子水平的变化及其意义[J]. 生殖医学杂志, 2008, 17(5): 342-345 |
| 作者姓名： | 阎华 许俊华 郭淑青 耿永巧 李立粉 |
| 作者单位： | 1. 河北医科大学第二医院妇产科,石家庄,050000 2. 河北定州武警8640部队医院妇产科,定州,073000 3. 河北内丘县中医院妇产科,内丘,054200 4. 河北宁晋县中西医结合医院妇产科,宁晋,055550 |
| 基金项目： | 河北省计划生育委员会科技计划项目 |
| 摘 要： | 目的通过检测子宫内膜异位症(EMs)患者血清及腹腔液中血小板衍生生长因子(PDGF)、血管细胞粘附分子-(VCAM-1)浓度,探讨PDGF和VCAM-1在EMs发病中的作用。方法选取手术后病理证实为EMs的40例患者为EMs组,其中I~II期17例,III~IV23例;非EMs组20例作为对照组。应用酶联免疫吸附法(ELISA)检测血清及腹腔液中PDGF和VCAM-1水平。结果EMs组血清及腹腔液中PDGF、VCAM-1水平均明显高于对照组(P<0.01)。随EMs期别的增加,其血清和腹腔液中PDGF、VCAM-1含量呈上升趋势;EMsIII~IV期水平显著高于I~II期(P<0.05)。EMs患者PDGF与VCAM-1呈正相关性(P<0.05)。结论EMs患者PDGF、VCAM-1表达水平升高,在EMs的发生发展中具有重要作用。 |
| 关 键 词： | 子宫内膜异位症 血小板衍生生长因子 血管细胞粘附分子-1 血清 腹腔液 |
Changes and significance of PDGF,VCAM-1 levels in sera and peritoneal fluid of patients with endometriosis |
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| YAN Hua,XU Jun-hua,GUO Shu-qing,GENG Yong-qiao,LI Li-fen. Changes and significance of PDGF,VCAM-1 levels in sera and peritoneal fluid of patients with endometriosis[J]. Journal of Reproductive Medicine, 2008, 17(5): 342-345 | |
| Authors: | YAN Hua XU Jun-hua GUO Shu-qing GENG Yong-qiao LI Li-fen |
| Affiliation: | YAN Hua1,XU Jun-hua2,GUO Shu-qing3,GENG Yong-qiao3,LI Li-fen41.Department of Obstetrics & Gynecology,Second Affiliated Hospital,Hebei Medical University,Shijiazhuang 0500002.Department of Obstetrics & Gynecology,Hebei Dingzhou 8640 Police Hospital,Dingzhou 0730003.Department of Obstetrics & Gynecology,Hebei Neiqiu Traditionad Medicine Hospital,Neiqiu 0542004.Department of Obstetrics & Gynecology,Hebei Ningjin Integrated Traditional , Western Medicine Hospital,Ningjin 055550 |
| Abstract: | Objective:To detect the concentrations of platelet derived growth factor(PDGF),vascular cellular adhesion molecule-1(VCAM-1) in sera and peritoneal fluid of patients with endometriosis and study their possible role in the development of endometriosis.Methods: Forty patients with endometriosis pathologically diagnosed after operation were selected as endometriosis group,with 17 patients at stageI-II and 23 at stage III-IV.Twenty patients without endometriosis were as control.The levels of PDGF,VCAM-1 in thei... |
| Keywords: | Endometriosis Platelet derived growth factor Vascular cellular adhesion molecule-1 Serum Peritoneal fluid |
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