T—2毒素对小鼠小肠的早期毒性作用

本文报告了 T-2毒素所致小鼠小肠损伤及其修复过程。中毒后1h 所有隐窝中有丝分裂像消失,且大部分隐窝上皮细胞发生退行变;4h 大部分上皮细胞死亡;8及12h 隐窝消失的数目逐渐增多;16h 有丝分裂像在一些隐窝中开始重新少数出现,并逐渐增多;24h 几乎所有隐窝形态均正常。文献中尚无 T-2毒素所致早期中毒后1h 小肠损伤形态学的资料,故本文填补了这一空白。

EARLY TOXIC EFFECT OF T-2 TOXIN ON MURINE SMALL INTESTINE

The process of injury in murine small intestine induced by T-2 toxin and its repair was reported in this paper.One hour after intoxication mitotic figures disappeared in all intestinal crypts and most epithelial cells of the crypts showed degenerative changes.At four hours a large part of the epithelial cells were dead.A number of crypts were lost at eight hours and that number increased at 12 hours.However,mitotic activity was resumed beginning from 16 hours and increased gradually afterwards.At 24 hours some crypts presented almost normal morphology.The early morphological changes in intestine induced by T-2 toxin has not reported yet in the literature,therefore this experiment filled this gap.Besides,the doses of T-2 toxin and of gamma-rays needed for inducing similar morphological changes and the possible difference in the mechanisms of action between these two kinds of toxic agents were discussed.