| 鹿药新呋甾皂苷的分离鉴定及活性研究 |
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| 引用本文： | 赵淑杰,杨利民,韩忠明,韩梅. 鹿药新呋甾皂苷的分离鉴定及活性研究[J]. 中国中药杂志, 2011, 36(24): 3453-3456 |
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| 作者姓名： | 赵淑杰 杨利民 韩忠明 韩梅 |
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| 作者单位： | 1. 吉林农业大学资源与环境学院,吉林长春,130118
2. 吉林农业大学中药材学院,吉林长春,130118 |
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| 基金项目： | 吉林省科技发展计划重大项目(20075022);吉林农业大学科研启动基金项目(201103) |
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| 摘 要： | 目的:研究鹿药Smilacina japonica根茎及根的化学成分及活性.方法:采用超声提取,柱色谱分离与纯化,根据理化性质及红外、质谱、一维、二维核磁共振等波谱方法鉴定结构,进行了体外抗肿瘤活性测定.结果:分离得到1个化合物,鉴定为26-O-β-D-吡喃葡萄糖基-(25R)-呋甾-5-烯3β,12,17α,22ζ,26-五醇-12-O-乙酰基-3-O-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷(1),该化合物具有抑制入肺腺癌SPC-A-1细胞生长的活性.结论:化合物1为新化合物.
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| 关 键 词： | 鹿药 呋甾皂苷 结构鉴定 核磁共振 化学成分 |
| 收稿时间： | 2011-06-13 |
Furosteroidal saponin from Smilacina japonica |
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| ZHAO Shujie,YANG Limin,HAN Zhongming and HAN Mei. Furosteroidal saponin from Smilacina japonica[J]. China Journal of Chinese Materia Medica, 2011, 36(24): 3453-3456 |
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| Authors: | ZHAO Shujie YANG Limin HAN Zhongming HAN Mei |
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| Affiliation: | ZHAO Shujie2,YANG Limin1,HAN Zhongming1,HAN Mei1 (1.College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China,2.College of Resources and Environment,China) |
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| Abstract: | Smilacina japonica is a perennial herb, belonging to Smilacina genus of Liliaceae. A new furosteroidal saponin (1) was isolated and purified from the ethanol extract of the rhizome of S. japonica by various column chromatography. Its structure was established as 26-O-beta-D-glucopyranosyl-(25R)-furost-5-en-3beta, 12, 17alpha, 22xi, 26-pentol-12-O-acetyle-3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranoside by physical and chemical properties and IR, MS, 1D, 2D NMR techniques. It showed strong cytotoxicity against the SPC-A-1 cancer cell lines. |
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| Keywords: | Smilacina japonica furosteroidal saponin identification NMR chemical constituents |
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