HLA antigens in patients with recrudescent herpes simplex infections |
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| Authors: | C. Legendre A. S. Russell M. Jeannet |
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| Affiliation: | Transplantation Immunology Unit, Division of Immunology and Allergology, Hôpital Cantonal Universitaire, Geneva, Switzerland |
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| Abstract: | We have assessed the humoral and cellular immune responses to HSV-1 antigen in normal controls, and in 47 subjects with recurrent cold sores. THe antigens at the HLA-ABC and DR loci were examined in the first group of 21 susceptible subjects. An apparent increase in prevalence of A9 seen in this group was confirmed in a prospective study of a further 26 subjects (P less than 0.0005). In contrast to previous studies, no relationship was noted between the immune responses and HLA antigens. |
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