| 大鼠血管移植模型的建立及改进 |
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| 引用本文： | 刘苏健,邓勇志,马捷.大鼠血管移植模型的建立及改进[J].山西医科大学学报,2007,38(10):955-957,F0003. |
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| 作者姓名： | 刘苏健 邓勇志 马捷 |
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| 作者单位： | 1. 北京航天总医院胸外科,北京,100076;山西医科大学第二医院心胸外科
2. 山西医科大学第二医院心胸外科 |
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| 摘 要： | 目的建立一种与冠脉旁路移植术后静脉桥再狭窄病理过程相似的动物模型。方法将一段游离的大鼠颈外静脉分支与同侧颈总动脉行端端吻合,分别于术后1 d,3 d,7 d,14 d,28 d取材,HE染色。结果可见静脉桥管腔狭窄,病理切片显示内膜不同程度增生。结论大鼠颈静脉颈动脉间置模型能真实反映冠脉旁路移植术后静脉桥狭窄的情况,是进一步研究防治静脉桥再狭窄的理想模型。
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| 关 键 词： | 模型 动物 移植 狭窄 大鼠 |
| 文章编号： | 1007-6611（2007）10-0955-03 |
| 修稿时间： | 2007-05-24 |
Construction of vein-to-artery interposition graft model in rats |
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| LIU Su-jian,DENG Yong-zhi,MA Jie.Construction of vein-to-artery interposition graft model in rats[J].Journal of Shanxi Medical University,2007,38(10):955-957,F0003. |
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| Authors: | LIU Su-jian DENG Yong-zhi MA Jie |
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| Institution: | Dept of Thoracic Surgery;General Hospital of Spaceflight;Beijing 100076;China |
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| Abstract: | Objective To construct the SD rat model of saphenous vein grafts restenosis after coronary artery bypass grafting. Methods Seventy-five male SD rats were undergone the vein-to-artery interposition,and commonly bred after operation.The specimen were detected at days 1,3,7,14 and 28 after operation,and tissue sections were observed by HE staining. Results Neointimal thickening was greater at the proximal and,to a lesser extent,distal ends,in comparison to the middle of the graft.There was hyperplasia in different degree.Interposition of vein-to-artery showed survival of vein graft endothelial cells.Conclusion The vein-to-artery interposition model is successfully established,and could be an ideal model for further preventing vein graft intimal hyperplasia after bypass grafting. |
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| Keywords: | model animals transplantation stenosis rats |
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