血栓调节蛋白在乳腺癌组织中的表达

目的探讨血栓凋节蛋白（TM）在乳腺癌组织中的表达。方法应州免疫组织化学法对94例乳腺癌、10例乳腺纤维腺瘤组织中的TM表达水平进行检测。结果TM存乳腺癌组织中的表达明显高于乳腺纤维腺瘤组织中的表达（P〈0．01）。在乳腺癌组织中TM的表达与临床分期、淋巴结转移状况有关，随着临床分期的增高，其阳性表达率逐渐下降（P〈0．05）。淋巴结阴性组阳性表达率为66．7％，淋巴结阳性组阳性表达率为44．2％fP〈0．05）。TM与肿瘤组织病理学分级、病理学类型、肿瘤最大径无统计学意义fP〉O．05）。结论TM表达水平可能与乳腺癌的发展、转移有关，有望成为判断乳腺癌患者病情发展和预后的一项新指标。

Expression of thrombomodulin in mammary carcinoma

Objective To investigate the expression of thrombomodulin （TM） in mammary carcinoma. Methods The expression of TM was detected by immunohistochemistry method in 94 cases of mammary carcinoma and 10 cases of mammary fibroadenoma. Results The expression of TM in mammary carcinoma was significantly higher than that in mammary fibroadenoma （P 〈0.01）. The expression of TM showed correlation with clinical stage, lymph node condition and the ex- pression rate of TM was gradually decreased with the progress of clinical stage （P 〈0.05）. The expression rate of TM was significantly higher in lymph node negative group than in lymph node positive group （P 〈0.05）. The expression of TM showed no correlation with histological grading, pathological type and tumor maximum size （P 〉0.05）. Conclusion TM may be used as a new biological index for judging progression and prognosis of mammary carcinoma.