| 结直肠癌组织中BRMS1 mRNA的表达及意义 |
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| 引用本文： | 年峰,袁圆,王海涛,芦华丽. 结直肠癌组织中BRMS1 mRNA的表达及意义[J]. 蚌埠医学院学报, 2018, 43(5): 614-616,620. DOI: 10.13898/j.cnki.issn.1000-2200.2018.05.015 |
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| 作者姓名： | 年峰 袁圆 王海涛 芦华丽 |
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| 作者单位： | 1. 安徽省蚌埠市中心医院 肿瘤内科, 233000;2. 蚌埠医学院 解剖学教研室, 安徽 蚌埠 233030;3. 安徽省蚌埠市中心医院 肿瘤外科, 233000;4. 安徽省蚌埠市中心医院 病理科, 233000 |
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| 摘 要： | 目的:探讨乳腺癌转移抑制基因1（BRMS1）mRNA在结直肠癌组织中的表达及临床意义。方法:采用RT-PCR法分别检测40例结直肠癌组织和20例正常结直肠组织中BRMS1 mRNA的表达，并分析其与各临床病理特征之间的关系。结果:BRMS1 mRNA在结直肠癌组织中低表达0.420±0.133，在正常结直肠组织中高表达0.836±0.102，差异有统计学意义（P<0.01）。结直肠癌组织中BRMS1 mRNA的表达水平与病人年龄、性别、肿瘤部位、肿瘤分化程度及浸润深度无关（P>0.05），而与淋巴结转移呈负相关关系（P<0.01）。结论:BRMS1 mRNA在结直肠癌组织中呈低表达，并有可能成为反映结直肠癌转移潜能的参考指标之一。
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| 关 键 词： | 结直肠肿瘤 转移抑制基因 BRMS1 逆转录聚合酶链式反应 |
| 收稿时间： | 2017-09-13 |
Expression of BRMS1 mRNA in colorectal carcinoma and its clinical significance |
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| NIAN Feng,YUAN Yuan,WANG Hai-tao,LU Hua-li. Expression of BRMS1 mRNA in colorectal carcinoma and its clinical significance[J]. Journal of Bengbu Medical College, 2018, 43(5): 614-616,620. DOI: 10.13898/j.cnki.issn.1000-2200.2018.05.015 |
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| Authors: | NIAN Feng YUAN Yuan WANG Hai-tao LU Hua-li |
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| Affiliation: | 1. Department of Oncology, Bengbu Central Hospital, Bengbu Anhui 233000;2. Department of Anatomy, Bengbu Medical College, Bengbu Anhui 233030, China;3. Department of General Surgery, Bengbu Central Hospital, Bengbu Anhui 233000;4. Department of Pathology, Bengbu Central Hospital, Bengbu Anhui 233000 |
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| Abstract: | Objective: To investigate the expression level of breast cancer metastasis suppressor 1(BRMS1) mRNA in colorectal carcinoma,and its clinical significance.Methods: The expression of BRMS1 mRNA in 40 colorectal carcinoma tissue specimens and 20 normal colorectum tissue specimens were detected using RT-PCR method,and the correlation of which with clinicopathologic features was analyzed.Results: The expression level of BRMS1 mRNA in colorectal carcinoma tissue(0.420±0.133)was lower than that in normal colorectum tissue(0.836±0.102) (P<0.01).The expression level of BRMS1 mRNA in colorectal carcinoma was not associated with age,sex,degree of differentiation and infiltrative depth(P>0.05),and was associated with lymph node metastasis(P<0.01).Conclusions: The expression level of BRMS1 mRNA in colorectal carcinoma tissue is low,which may be related to the lymph node metastasis of colorectal carcinoma. |
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