丁苯酞软胶囊治疗脑小血管病伴认知功能损害病人的临床疗效及对血流灌注的影响

目的:探讨丁苯酞软胶囊治疗脑小血管病病人认知功能损害的临床疗效及对血流灌注的影响。方法:选取脑小血管病病人120例，按照随机数字法分为观察组和对照组，每组60例，对照组给予常规降压、调脂、改善循环等治疗，观察组在对照组基础上给予丁苯酞治疗，疗程均为1个月，观察治疗前后简易精神状态检查量表（MMSE）及蒙特利尔量表（MOCA）评分，并对所有病人治疗前后进行64 排螺旋 CT 灌注成像检查，计算血流灌注参数值变化。结果:治疗前，2组MMSE和MOCA评分比较差异均无统计学意义（P>0.05），治疗后2组MMSE 及 MOCA 评分均较治疗前显著升高（P<0.01），且观察组升高更为明显（P<0.01）。治疗前2组血流速度、脑血流量及平均通过时间差异均无统计学意义（P>0.05），治疗后2组血流速度、脑血流量及平均通过时间均较治疗前显著改善（P<0.05~P<0.01），且观察组改善均更为明显（P<0.01）。结论:丁苯酞软胶囊可改善脑小血管病病人的认知功能，提高病灶区脑血流量，且安全有效，值得临床推广。

Clinical curative effect of butylphthalide soft capsule in patients with cerebral small vessel disease complicated with cognitive impairment,and its influence on blood perfusion

Objective:To investigate the clinical curative effects of butylphthalide soft capsule on cerebral small vessel patients disease complicated with cognitive impairment,and its influence on blood perfusion. Methods:One hundred and twenty patients with cerebral small vascular disease were randomly divided into the observation group and control group(60 cases each group). The control group was conventionally treated with reducing pressure, adjusting fat and improving circulation, and the observation group was additionally treated with butylphthalide based on control group for 1 month. The simple mental state examination( MMSE) and montreal scale( MOCA) scores in two groups before and after treatment were recorded. Two groups were examined using 64-slice spiral CT perfusion imaging,to calculate perfusion parameters. Results:Before treatment,the differences of MMSE and MOCA scores between two groups were not statistically significant(P>0. 05),the MMSE and MOCA scores in two groups after treatment significantly increased, and the increasing degree of which in observation group was more obvious. Before treatment, the differences of blood flow velocity, cerebral blood volume and mean transition time between two groups were not statistically significant(P>0. 05),the blood flow velocity, cerebral blood volume and mean transition time in two groups after treatment significantly improved(P<0. 05 to P<0. 01),and the improving degree of which in observation group was more obvious(P<0. 01). Conclusions:Butylphthalide soft capsule can improve the cognitive function and increase the blood flow of lesions,which is safe and effective,and worthy of clinical promotion.