颈围与糖尿病胰岛素抵抗相关性研究

目的:研究不同性别2型糖尿病（T2DM）中颈围（NC）与胰岛素抵抗（IR）相关性。方法:将糖尿病病人165例分为男女两个群体研究，分别测量体质量指数（BMI）、NC、腰围（WC）、臀围（HC）、腰臀比（WHR）及血生化指标，比较不同性别各参数有无差异。spearman线性相关分析NC与各参数相关性以及NC、WC与胰岛素抵抗指数（HOMA-IR）相关性。logistic回归分析NC是否为T2DM危险因素。结果:在男性组，仅年龄与NC无相关关系（P>0.05），高密度脂蛋白（HDL）与NC呈负相关关系（P<0.01），其余指标均与NC呈正相关关系（P<0.05~P<0.01）；在女性组，年龄和臀围2个指标与NC无相关关系（P>0.05），HDL与NC呈负相关关系（P<0.01），其余指标均与NC呈正相关关系（P<0.05~P<0.01），尤其NC与BMI、WC有很强的正相关性；校正年龄及性别后，NC、WC、TG均是T2DM危险因素，HDL则是保护因素。结论:NC与IR呈正相关，是T2DM的危险因素，且相较于BMI、WC等其他人体测量参数有更多的优势，可作为评估T2DM更好的指标，临床意义重大。

Correlation study between neck circumference and insulin resistance in type 2 diabetes mellitus patients

Objective:To study the correlation between neck circumference(NC) and insulin resistance(IR) in different genders patients with type 2 diabetes mellitus(T2DM). Methods:A total of 165 diabetic patients were divided into the male group and female group. The body mass index ( BMI ) , NC, waist circunference ( WC ) , waist-hip ratio ( WHR ) , hip circumference ( HC ) and blood biochemical indicators in two groups were measured, and which was analyzed. The correlations between NC and each parameter, and between NC,WC and HOMA-IR were analyzed using spearman linear correlation analysis. Logistic regression was used to analyze that whether the NC was or not one of risk factor of T2DM. Results:In male group,the age was not correlation with NC(P>0. 05),the hight-density lipoprotein(HDL) was negatively correlated with NC(P<0. 01),and other indicators were positively correlated with NC (P<0. 05 to P <0. 01). In female group,the age and hip circumference were not correlation with NC(P <0. 05),the HDL was negatively correlated with NC(P<0. 01),other indicators were positively correlated with NC(P<0. 05 to P<0. 01),and especially the NC was strongly positive correlation with BMI and WC(P<0. 05). After adjusting age and gender,the NC,WC and TG were the risk factors of T2DM,while the HDL was the protective factor of T2DM. Conclusions:NC is positively related to IR,a risk factor of T2DM, and which has more advantages than other parameters ( such as BMI and WC ) . NC can be used as a better indicator in evaluating T2DM,which has great clinical significance.