| 恶性疟原虫抗独特型抗体的初步研究 |
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| 引用本文： | 林来兴妹,李纪良,常文生,李英杰. 恶性疟原虫抗独特型抗体的初步研究[J]. 南方医科大学学报, 1994, 0(3) |
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| 作者姓名： | 林来兴妹 李纪良 常文生 李英杰 |
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| 作者单位： | Linlai Xinmei，Li Jiliang，Chang Wensheng，et al Department of Malaria Immunology |
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| 摘 要： | ![]()
用抗恶性疟原虫单克隆抗体１３Ａ２，制备兔抗血清，经ＢＡＬＢ／ｃ－ＩｇＧ－Ｓｅｐｈａｒｏｓｅ４Ｂ和１３Ａ２ＭｃＡｂ－Ｓｅｐｈａｒｏｓｅ４Ｂ柱提纯，得到抗独特型抗体（Ａｂ２）。免疫双扩散试验和ＥＬＩＳＡ试验表明：抗独特型抗体仅与１３Ａ２ＭｃＡｂ反应。４ｉ试验显示：当恶性疟原虫抗原浓度为８０μｇ／ｍｌ，对１３Ａ２Ｉｄ－Ａｎｔｉｌ３Ａ２Ｉｄ系统产生８１％的抗体结合抑制率，而伯氏疟原虫和诺氏疟原虫抗原检测，抗体结合抑制率分别为２７％和２．５％。兔抗血清中抗Ａｂ２抗体（Ａｂ３）滴度为１：６４０，提示此抗独特型抗体可替代原始抗原诱生抗恶性疟抗体。
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| 关 键 词： | 疟原虫，单克隆抗体，抗独特型抗体，4i试验，免疫诊断 |
Preliminary study on anti-idiotypic antibody against monoclonalantibody specific for asexual antigen of Plasmodium falciparum |
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| Linlai Xinmei,Li Jiliang,Chang Wensheng,et al. Preliminary study on anti-idiotypic antibody against monoclonalantibody specific for asexual antigen of Plasmodium falciparum[J]. Journal of Southern Medical University, 1994, 0(3) |
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| Authors: | Linlai Xinmei Li Jiliang Chang Wensheng et al |
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| Affiliation: | Linlai Xinmei,Li Jiliang,Chang Wensheng,et al Department of Malaria Immunology |
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| Abstract: | ![]()
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| Keywords: | P.faliparum anti-idiotypic antibody 4i assay immunodiagnosis vaccineProject Supported by National Natural science Foundation of China |
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