Effects of Allergina on the Treatment of Otitis Media with Effusions |
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Authors: | Hyun-Ja Jeong Seung-Heon Hong Sung-Chul Kim Eun-Jeong Park Chul-Ho Jang Kyung-Suk Kim Hyung-Min Kim |
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Affiliation: | (1) Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, 570-749, Republic of Korea;(2) Korea Institute of Oriental Pharmacy. Division of Biological Sciences, College of Natural Science, Chonbuk National University, Chonju, Chonbuk, 561-756, Republic of Korea;(3) Korea Institute of Oriental Pharmacy, Korea;(4) College of Oriental Medicine, Korea;(5) Wonkwang School of Medicine, Wonkwang University, Iksan, Chonbuk, 570-749, Republic of Korea;(6) Division of Biological Sciences, College of Natural Science, Chonbuk National University, Chonju, Chonbuk, 561-756, Republic of Korea;(7) Korea Institute of Oriental Pharmacy. The Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, 570-749, Republic of Korea |
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Abstract: | The number of pediatric patients with recurrent otitis media with effusions (ROMEs) is increasing because of the frequency of recurrence. The herbal combination Allergina is used for inflammatory-disease treatment in the Republic of Korea; in our study, the patients with ROME were treated with either Allergina (11 ears) or antibiotics (13 ears). We analyzed the levels of cytokines in middle-ear effusions (MEEs) and compared these levels in the Allergina-treated patients with those in the antibiotics-treated patients. The mean levels of interleukin (IL)-2 and IL-4 in MEEs were significantly higher in the Allergina-treated patients than in the antibiotics-treated patients, whereas levels of IL-1, IL-6, IL-8, and tumor necrosis factor (TNF)- in MEEs were significantly lower in the Allergina-treated patients than in the antibiotics-treated patients. Clinical signs of ROME disappeared markedly after all the patients were given an oral administration of Allergina. Our experimental studies provide evidence that Allergina may be beneficial in the treatment of ROME by regulating cytokine production. |
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Keywords: | ROME Allergina cytokine MEE |
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