IL-23在鼻息肉中的表达及其意义

目的检测IL-23在鼻息肉（nasal polyp,NP）组织中的表达,探讨其在鼻息肉发病中的作用。方法收集15例鼻息肉标本（NP组）和15例在鼻中隔偏曲矫正手术中根据需要部分切除下鼻甲黏膜组织（对照组）,分别采用免疫组织化学方法和RT-PCR方法检测两组IL-23蛋白和IL-23p19mRNA表达水平。结果 NP组IL-23蛋白阳性表达炎性浸润细胞数明显多于对照组,单位目标面积光密度均值（0.321±0.023）明显高于对照组（0.199±0.011）,差异有统计学意义（P〈0.01）;IL-23p19mRNA表达水平（0.676±0.077）明显高于对照组（0.212±0.015）,差异有统计学意义（P〈0.01）。结论IL-23可能在参与了NP发病过程。

Expression of IL-23 in nasal polyps and its significance

Objective To investigate the expression and role of interleukin-23（IL-23） in nasal polyp patients.Methods NP tissues of 15 nasal polyp（NP） patients and 15 simple deviations of normal inferior turbinate tissues of nasal septum patients were collected.mRNA and protein expression of IL-23 were detected by means of immunohistochemistry and RT-PCR.Results Immunohistochemistry staining demonstrated that there were far more IL-23 positive cells in NP patients than in normal controls.The average expression level of IL-23 protein in NP tissues（0.321±0.023） was significantly different（P0.01） from that of normal inferior turbinate tissues（0.199±0.011）.RT-PCR demonstrated that the average expression level of IL-23p19mRNA in NP tissues（0.676±0.077） was significantly different（P0.01） from that in normal inferior turbinate tissues（0.212±0.015）.Conclusions IL-23 may be involved in the chronic inflammation of NP.