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| 环扁桃酯对大鼠血液流变性及血栓形成的影响 | |
| 引用本文： | 张熠,张正义,关华.环扁桃酯对大鼠血液流变性及血栓形成的影响[J].中国血液流变学杂志,2006,16(4):523-525. |
| 作者姓名： | 张熠 张正义 关华 |
| 作者单位： | 1. 苏州大学药理教研室,江苏苏州,215007 2. 常州四药制药有限公司,江苏常州,213000 3. 常州戚墅堰医院,江苏常州,213011 |
| 摘 要： | 目的研究环扁桃酯对血流变和血栓形成的影响。方法测定环扁桃酯高、低剂量组大鼠的全血粘度、血小板聚集率、红细胞压积、血栓湿重,并与正常对照组、阿司匹林组进行比较。结果环扁桃酯的高剂量组降低全血粘度的效果最显著,高切变率80s~(-1)降低率为19．5％,低切变率20s~(-1)降低率为26．2％;环扁桃酯的高剂量组使血小扳聚集率明显降低,最大聚集率下降了29．2％;与空白对照组比较,环扁桃酯高剂量组使血栓湿重明显降低。结论提示环扁桃酯是改善血流变及血栓形成的有效药物。 |
| 关 键 词： | 环扁桃酯 血液流变学 血栓形成 |
| 文章编号： | 1009-881X(2006)04-0523-03 |
| 收稿时间： | 2006-05-31 |
| 修稿时间： | 2006年5月31日 |
Effect of Cyclandelate on Hemorrheology and Thrombosis in Rats |
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| ZHANG Yi,ZHANG Zheng-yi,GUAN Hua.Effect of Cyclandelate on Hemorrheology and Thrombosis in Rats[J].Chinese Journal of Hemorheology,2006,16(4):523-525. | |
| Authors: | ZHANG Yi ZHANG Zheng-yi GUAN Hua |
| Institution: | 1.Pharmacology Department of Suzhou University, Suzhou 215007;2.Changzhou Siyao Pharmaceuticals CO, LTD,Changzhou 213000;3.The Hospital of Qishuyan,Changzhou 213011 |
| Abstract: | Objective To study the effect of Cyclandelate on hemorrheology and thrombosis.Methods We determined the change of blood viscosity,platelet aggregation,haematocrit,thrombosis with drugs.Results High dose of Cyclandelate reduced blood viscosity obyiously 19.5% in high shear rate(80s~(-1))and 26.2 % in low shear rate (20s~(-1)).lt could inhibit platelet aggregation,the maximum ADP-induced platelet aggregation was reduced by 29.2%. It also increased the weight of wet thrombus.Conclusion These results suggested Cyclandelate was an effective agent to improve hemorrheology. |
| Keywords: | Cyclandelate hemorrheology thrombosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |