C反应蛋白1059G/C基因多态性与急性冠脉综合征的相关性研究

目的探讨昆明地区汉族人群中血清C反应蛋白1059G/C基因多态性与急性冠脉综合征之间的相关性。方法采用DNA测序,对100例急性冠脉综合征(acute coronary syndromes,ACS)患者和100例健康体检者的基因型进行鉴定,结合冠状动脉造影结果进行分析。结果 C反应蛋白1059G/C基因多态性等位基因和基因型的分布频率符合Hardy-Weinberg平衡(x~2=0.297,P0.05)。两组的1059G/C基因型和等位基因的分布趋势相同,差异无显著性(P0.05)。冠状动脉病变程度不受1059G/C基因多态性的影响(x~2=1.374,P0.05)。结论急性冠脉综合征患者冠状动脉病变程度可能不受1059G/C基因多态性的影响。

The correlation study between the 1059G/C gene polymorphism of C reactive protein and acute coronary syndrome(ACS)

Objective Study the correlation between the 1059G/C gene polymorphism of C reactive protein and ACS among the Han people in Kunming. Methods 100 patients with ACS and 100 health were brought into this research, the gene type was i-dentified by DNA sequencing, then analyzed the results combining the coronary arteriongraphy. Results The distribution frequency of 1059G/C's allele and gene type met with the Hardy Weinberg balance(X~2 =0. 297,P>0. 05). There didn't have obvious difference between the two groups. The degree of coronary artery disease was not affected by the gene polymorphism of 1059G/C. Conclusion For the patient with ACS, the pathological change of coronary artery could not be affected by the gene polymorphism of 1059G/C.