高校学生接种重组酵母基因乙肝疫苗3年后免疫效果观察

目的　了解国产 5 μg重组酵母基因乙肝疫苗对高校学生的免疫效果 ,为推广接种提供依据。 方法　整群追踪观察 395 6例研究对象免疫效果。结果　免疫接种后第 3年 ,研究对象乙肝表面抗体 (抗 -HBs)阳性率明显高于新生 (P <0 .0 0 5 )。 5 μg重组酵母基因乙肝疫苗 0、1、6月方案接种后第 3年 ,抗 -HBs阳性率为 33.80 %。抗 -HBs高校学生接种 1针乙肝疫苗 3年后有近 11%的人阴转。免疫接种后第 3年女生抗体阳性率显著高于男生 (P <0 .0 0 5 )。结论　高校学生接种乙肝疫苗对于预防乙肝有积极意义。适当加大酵母基因乙肝疫苗免疫剂量 ,可提高免疫持久性。

The Observation of the Immunity Effect on College Students with the 5 Micrograms Recombinant Yeast-derived Hepatitis B Vaccine

Objective To get a better understanding of the immunity effect on college students with domestic 5 micrograms recombinant yeast-derived hepatitis B vaccine. Method The anti-hepatitis B surface antigen was detected before the vaccine and three years later. Results The antibody positive rate three years later was obviously higher than before vaccination. Three years later, the positive rate of the students who received three dose vaccines at 0,1,6 months was 33.80%. The positive rate of the students who had Anti-HBs before they received one dose vaccine was 89.01%. The total positive rate was 51.57%. There was significant difference between the female students and the male students, P<0.005. Conclusions Anti-HBs Positive rate of college students was not good after they received three dose vaccines. Even for the students who had Anti-HBs and received one dose vaccine, there were still 11% or so who became negative three years later.