肿瘤标志物联合检测对原发性肝癌的诊断价值

目的:探讨肿瘤标志物（testing multi-tumor,TM）联合检测对原发性肝癌的诊断价值。方法:应用电化学发光法定量测定46例原发性肝癌患者、32例良性肝病患者、40例健康体检者血清中糖类抗原199（CA-199）、神经特异性烯醇酶（NSE）、癌胚抗原（CEA）、糖类抗原242（CA-242）、血清铁蛋白（FERR）、人绒毛膜促性腺激素（HCG）、甲胎蛋白（AFP）、游离前列腺特异性抗原（FPSA）、前列腺特异抗原（TPSA）、糖类抗原125（CA-125）、生长激素（HGH）、糖类抗原153（CA-153）12种TM的浓度。结果:肝癌组CA-199、CEA、CA-242、Ferritin、AFP、CA-153阳性率相对于良性肝病组及健康对照组显著增高（P<0.01）；肝癌组CA-199、CEA、CA-242、Ferritin、AFP、CA-153联合检测相对于健康对照组阳性率及敏感性显著增高（P<0.01）。结论:CA-199、CEA、CA-242、Ferritin、AFP、CA-153联合检测有助于提高原发性肝癌阳性检出率。

Multi - tumor markers combined detection in diagnosis of primary hepatocellular carcinoma

Objective:To study the serum tumor markers (TM) joint detection clinical value in the diagnosis of hepatic cancer.Methods:The serum levels of 12 tumor markers，including CA-199，NSE，CEA，CA-242，CA-125，CA-153，AFP，Ferritin，FPSA，PSA，β-HCG and HGH were measured in 46 cases with liver cancer，32 cases with benign liver lesion and 40 healthy canses by electrochemiluminescence ECL.Results:In liver cancer group,CA-199,CEA,CA-242,Ferritin,AFP,CA-153 serum level was higher than benign liver disease group and control group(P<0.01).In liver cancer group CA-199,CEA,CA-242,Ferritin,AFP,CA-153 joint detection level was higher than benign liver disease group and control group(P<0.01).Conclusion:The joint detection of CA-199、CEA、CA-242、Ferritin、AFP、CA-153 is helpful for diagnosis of liver cancer.